Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C789
  Reference Plasmid   NZ_CP062962.1
  Reference Plasmid Size   38824
  Reference Plasmid GC Content   0.56
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0101274 MDKOFCIE_00023 22274 7 Skin 0.54 protein_coding synonymous_variant LOW 366T>C Tyr122Tyr
M0101275 MDKOFCIE_00021 21106 3 Skin 0.23 protein_coding missense_variant MODERATE 479G>A Arg160His
M0101276 MDKOFCIE_00021 21121 3 Skin 0.23 protein_coding missense_variant MODERATE 464A>G Tyr155Cys
M0101277 MDKOFCIE_00021 21122 3 Skin 0.23 protein_coding missense_variant MODERATE 463T>C Tyr155His
M0101278 MDKOFCIE_00021 21124 3 Skin 0.23 protein_coding stop_gained HIGH 461G>A Trp154*
M0101279 MDKOFCIE_00021 21181 3 Skin 0.23 protein_coding missense_variant MODERATE 404T>C Met135Thr
M0101280 MDKOFCIE_00021 21182 3 Skin 0.23 protein_coding missense_variant MODERATE 403A>G Met135Val
M0101281 MDKOFCIE_00021 21189 3 Skin 0.23 protein_coding synonymous_variant LOW 396G>C Gly132Gly
M0101282 MDKOFCIE_00021 21246 3 Skin 0.23 protein_coding synonymous_variant LOW 339A>C Gly113Gly
M0101283 MDKOFCIE_00021 21279 3 Skin 0.23 protein_coding synonymous_variant LOW 306C>T Ser102Ser
M0101284 MDKOFCIE_00021 21281 3 Skin 0.23 protein_coding missense_variant MODERATE 304A>G Ser102Gly
M0101285 MDKOFCIE_00021 21302 3 Skin 0.23 protein_coding missense_variant MODERATE 283T>C Trp95Arg
M0101286 MDKOFCIE_00021 21318 3 Skin 0.23 protein_coding synonymous_variant LOW 267A>G Val89Val
M0101287 MDKOFCIE_00021 21328 3 Skin 0.23 protein_coding missense_variant MODERATE 257T>A Val86Asp
M0101288 MDKOFCIE_00021 21329 3 Skin 0.23 protein_coding missense_variant MODERATE 256G>A Val86Ile
M0101289 MDKOFCIE_00021 21358 3 Skin 0.23 protein_coding missense_variant MODERATE 227A>G Asp76Gly
M0101290 MDKOFCIE_00021 21380 3 Skin 0.23 protein_coding missense_variant MODERATE 205C>G His69Asp
M0101291 MDKOFCIE_00021 21418 3 Skin 0.23 protein_coding missense_variant MODERATE 167G>A Gly56Asp
M0101292 MDKOFCIE_00021 21465 3 Skin 0.23 protein_coding synonymous_variant LOW 120C>A Arg40Arg
M0101293 MDKOFCIE_00021 21476 3 Skin 0.23 protein_coding missense_variant MODERATE 109T>C Trp37Arg
M0101294 MDKOFCIE_00021 21503 3 Skin 0.23 protein_coding missense_variant MODERATE 82G>C Asp28His
M0101295 MDKOFCIE_00021 21519 3 Skin 0.23 protein_coding synonymous_variant LOW 66A>C Gly22Gly
M0101296 MDKOFCIE_00021 21523 3 Skin 0.23 protein_coding missense_variant MODERATE 62T>C Phe21Ser
M0101297 MDKOFCIE_00021 21554 3 Skin 0.23 protein_coding missense_variant MODERATE 31G>A Ala11Thr
M0101298 MDKOFCIE_00021 21572 3 Skin 0.23 protein_coding missense_variant MODERATE 13A>G Lys5Glu
M0101299 MDKOFCIE_00021 21587 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -3T>C None
M0101300 MDKOFCIE_00021 21599 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -15T>C None
M0101301 MDKOFCIE_00021 21661 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -77T>G None
M0101302 MDKOFCIE_00021 21673 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -89T>C None
M0101303 MDKOFCIE_00021 21698 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -114T>A None
M0101304 MDKOFCIE_00021 21704 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -120C>T None
M0101305 MDKOFCIE_00022 21778 3 Skin 0.23 protein_coding synonymous_variant LOW 63C>T Ile21Ile
M0101306 MDKOFCIE_00022 21792 3 Skin 0.23 protein_coding missense_variant MODERATE 77A>G Gln26Arg
M0101307 MDKOFCIE_00022 21829 3 Skin 0.23 protein_coding synonymous_variant LOW 114A>G Val38Val
M0101308 MDKOFCIE_00022 21859 3 Skin 0.23 protein_coding synonymous_variant LOW 144C>T Ile48Ile
M0101309 MDKOFCIE_00022 21861 3 Skin 0.23 protein_coding missense_variant MODERATE 146C>G Pro49Arg
M0101310 MDKOFCIE_00022 21871 3 Skin 0.23 protein_coding synonymous_variant LOW 156A>C Ser52Ser
M0101311 MDKOFCIE_00022 21889 3 Skin 0.23 protein_coding synonymous_variant LOW 174A>G Pro58Pro
M0101312 MDKOFCIE_00021 21897 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -313A>C None
M0101313 MDKOFCIE_00021 21908 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -324A>G None
M0101314 MDKOFCIE_00023 21951 3 Skin 0.23 protein_coding missense_variant MODERATE 43A>G Ser15Gly
M0101315 MDKOFCIE_00023 21952 3 Skin 0.23 protein_coding missense_variant MODERATE 44G>C Ser15Thr
M0101316 MDKOFCIE_00023 22025 3 Skin 0.23 protein_coding synonymous_variant LOW 117T>C His39His
M0101317 MDKOFCIE_00023 22133 3 Skin 0.23 protein_coding synonymous_variant LOW 225A>G Gln75Gln
M0101318 MDKOFCIE_00023 22178 3 Skin 0.23 protein_coding synonymous_variant LOW 270A>G Ser90Ser
M0101319 MDKOFCIE_00023 22194 3 Skin 0.23 protein_coding missense_variant MODERATE 286A>G Asn96Asp
M0101320 MDKOFCIE_00023 22322 3 Skin 0.23 protein_coding synonymous_variant LOW 414G>A Gly138Gly
M0101321 MDKOFCIE_00023 22324 3 Skin 0.23 protein_coding missense_variant MODERATE 416T>A Phe139Tyr
M0101322 MDKOFCIE_00023 22332 3 Skin 0.23 protein_coding missense_variant MODERATE 424A>T Ser142Cys
M0101323 MDKOFCIE_00021 22431 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -847A>G None
M0101324 MDKOFCIE_00021 22445 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -861G>A None
M0101325 MDKOFCIE_00021 22483 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -899A>C None
M0101326 MDKOFCIE_00021 22485 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -901C>A None
M0101327 MDKOFCIE_00021 22525 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -941G>A None
M0101328 MDKOFCIE_00021 22528 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -944T>C None
M0101329 MDKOFCIE_00021 22536 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -952T>C None
M0101330 MDKOFCIE_00021 22538 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -954C>T None
M0101331 MDKOFCIE_00021 22553 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -969T>C None
M0101332 MDKOFCIE_00021 22556 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -972C>G None
M0101333 MDKOFCIE_00021 22559 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -975G>A None
M0101334 MDKOFCIE_00021 22582 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -998T>C None
M0101335 MDKOFCIE_00021 22599 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1015A>G None
M0101336 MDKOFCIE_00021 22603 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1019T>C None
M0101337 MDKOFCIE_00021 22634 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1050A>G None
M0101338 MDKOFCIE_00021 22636 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1052T>G None
M0101339 MDKOFCIE_00021 22648 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1064T>C None
M0101340 MDKOFCIE_00021 22653 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1069G>A None
M0101341 MDKOFCIE_00021 22654 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1070A>G None
M0101342 MDKOFCIE_00021 22655 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -1071T>G None
M0101343 MDKOFCIE_00025 22662 3 Skin 0.23 protein_coding synonymous_variant LOW 6T>G Thr2Thr
M0101344 MDKOFCIE_00025 22667 3 Skin 0.23 protein_coding missense_variant MODERATE 11A>T Asn4Ile
M0101345 MDKOFCIE_00025 22674 3 Skin 0.23 protein_coding synonymous_variant LOW 18A>G Gln6Gln
M0101346 MDKOFCIE_00025 22704 3 Skin 0.23 protein_coding synonymous_variant LOW 48A>G Thr16Thr
M0101347 MDKOFCIE_00025 22737 3 Skin 0.23 protein_coding synonymous_variant LOW 81A>G Ala27Ala
M0101348 MDKOFCIE_00025 22833 3 Skin 0.23 protein_coding synonymous_variant LOW 177A>G Val59Val
M0101349 MDKOFCIE_00025 22851 3 Skin 0.23 protein_coding synonymous_variant LOW 195T>C Phe65Phe
M0101350 MDKOFCIE_00025 22854 3 Skin 0.23 protein_coding synonymous_variant LOW 198C>G Leu66Leu
M0101351 MDKOFCIE_00025 22857 3 Skin 0.23 protein_coding synonymous_variant LOW 201T>C Val67Val
M0101352 MDKOFCIE_00025 23015 3 Skin 0.23 protein_coding missense_variant MODERATE 359C>T Thr120Ile
M0101353 MDKOFCIE_00026 23078 3 Skin 0.23 protein_coding synonymous_variant LOW 30A>C Ala10Ala
M0101354 MDKOFCIE_00026 23081 3 Skin 0.23 protein_coding synonymous_variant LOW 33C>T Ala11Ala
M0101355 MDKOFCIE_00026 23099 3 Skin 0.23 protein_coding synonymous_variant LOW 51T>C Pro17Pro
M0101356 MDKOFCIE_00026 23195 3 Skin 0.23 protein_coding synonymous_variant LOW 147A>G Ala49Ala
M0101357 MDKOFCIE_00026 23201 3 Skin 0.23 protein_coding synonymous_variant LOW 153A>G Leu51Leu
M0101358 MDKOFCIE_00026 23216 3 Skin 0.23 protein_coding synonymous_variant LOW 168T>C His56His
M0101359 MDKOFCIE_00026 23232 3 Skin 0.23 protein_coding missense_variant MODERATE 184G>T Val62Phe
M0101360 MDKOFCIE_00026 23233 3 Skin 0.23 protein_coding missense_variant MODERATE 185T>C Val62Ala
M0101361 MDKOFCIE_00026 23240 3 Skin 0.23 protein_coding synonymous_variant LOW 192A>G Leu64Leu
M0101362 MDKOFCIE_00026 23260 3 Skin 0.23 protein_coding missense_variant MODERATE 212G>C Gly71Ala
M0101363 MDKOFCIE_00026 23309 3 Skin 0.23 protein_coding synonymous_variant LOW 261A>G Arg87Arg
M0101364 MDKOFCIE_00026 23516 3 Skin 0.23 protein_coding synonymous_variant LOW 468T>C Arg156Arg
M0101365 MDKOFCIE_00026 23546 3 Skin 0.23 protein_coding synonymous_variant LOW 498C>T Ala166Ala
M0101366 MDKOFCIE_00026 23555 3 Skin 0.23 protein_coding synonymous_variant LOW 507A>G Ser169Ser
M0101367 MDKOFCIE_00026 23582 3 Skin 0.23 protein_coding synonymous_variant LOW 534G>C Val178Val
M0101368 MDKOFCIE_00026 23586 3 Skin 0.23 protein_coding missense_variant MODERATE 538T>G Ser180Ala
M0101369 MDKOFCIE_00026 23612 3 Skin 0.23 protein_coding synonymous_variant LOW 564C>T Asp188Asp
M0101370 MDKOFCIE_00026 23628 3 Skin 0.23 protein_coding missense_variant MODERATE 580T>C Phe194Leu
M0101371 MDKOFCIE_00026 23639 3 Skin 0.23 protein_coding synonymous_variant LOW 591C>A Thr197Thr
M0101372 MDKOFCIE_00026 23682 3 Skin 0.23 protein_coding missense_variant MODERATE 634G>A Gly212Ser
M0101373 MDKOFCIE_00026 23751 3 Skin 0.23 protein_coding missense_variant MODERATE 703G>A Asp235Asn
M0101374 MDKOFCIE_00026 23768 3 Skin 0.23 protein_coding synonymous_variant LOW 720T>C Val240Val
M0101375 MDKOFCIE_00026 23771 3 Skin 0.23 protein_coding synonymous_variant LOW 723T>C His241His
M0101376 MDKOFCIE_00026 23840 3 Skin 0.23 protein_coding synonymous_variant LOW 792A>G Glu264Glu
M0101377 MDKOFCIE_00026 23869 3 Skin 0.23 protein_coding missense_variant MODERATE 821T>C Met274Thr
M0101378 MDKOFCIE_00026 23925 3 Skin 0.23 protein_coding missense_variant MODERATE 877G>T Ala293Ser
M0101379 MDKOFCIE_00026 23927 3 Skin 0.23 protein_coding synonymous_variant LOW 879A>G Ala293Ala
M0101380 MDKOFCIE_00021 24041 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2457T>C None
M0101381 MDKOFCIE_00021 24086 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2502T>C None
M0101382 MDKOFCIE_00021 24094 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2510C>T None
M0101383 MDKOFCIE_00021 24100 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2516C>G None
M0101384 MDKOFCIE_00027 24116 3 Skin 0.23 protein_coding synonymous_variant LOW 6A>G Lys2Lys
M0101385 MDKOFCIE_00027 24131 3 Skin 0.23 protein_coding missense_variant MODERATE 21G>C Leu7Phe






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term