Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C880
  Reference Plasmid   NZ_CP072238.1
  Reference Plasmid Size   102111
  Reference Plasmid GC Content   0.42
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0187136 HEOOCNGA_00104 83950 4 Gut 0.04 protein_coding missense_variant MODERATE 550A>G Ile184Val
M0187137 HEOOCNGA_00071 59390 4 Gut 0.04 protein_coding missense_variant MODERATE 17G>A Gly6Glu
M0187138 HEOOCNGA_00093 73539 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -181T>C None
M0187139 HEOOCNGA_00093 73566 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -154T>C None
M0187140 HEOOCNGA_00093 73568 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -152C>T None
M0187141 HEOOCNGA_00062 53320 3 Gut 0.03 protein_coding missense_variant MODERATE 622A>G Thr208Ala
M0187142 HEOOCNGA_00062 53739 3 Gut 0.03 protein_coding synonymous_variant LOW 1041G>A Lys347Lys
M0187143 HEOOCNGA_00094 74799 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -74G>T None
M0187144 HEOOCNGA_00094 74800 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -73G>T None
M0187145 HEOOCNGA_00094 74804 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -69T>A None
M0187146 HEOOCNGA_00094 74980 3 Gut 0.03 protein_coding synonymous_variant LOW 108G>A Thr36Thr
M0187147 HEOOCNGA_00095 75363 3 Gut 0.03 protein_coding synonymous_variant LOW 303G>A Glu101Glu
M0187148 HEOOCNGA_00095 75408 3 Gut 0.03 protein_coding synonymous_variant LOW 348G>A Lys116Lys
M0187149 HEOOCNGA_00095 75411 3 Gut 0.03 protein_coding synonymous_variant LOW 351G>A Lys117Lys
M0187150 HEOOCNGA_00095 75423 3 Gut 0.03 protein_coding synonymous_variant LOW 363T>C Ala121Ala
M0187151 HEOOCNGA_00095 75445 3 Gut 0.03 protein_coding missense_variant MODERATE 385G>C Val129Leu
M0187152 HEOOCNGA_00095 75446 3 Gut 0.03 protein_coding missense_variant MODERATE 386T>C Val129Ala
M0187153 HEOOCNGA_00096 75478 3 Gut 0.03 protein_coding synonymous_variant LOW 6A>G Lys2Lys
M0187154 HEOOCNGA_00096 75481 3 Gut 0.03 protein_coding synonymous_variant LOW 9C>T Pro3Pro
M0187155 HEOOCNGA_00096 75483 3 Gut 0.03 protein_coding missense_variant MODERATE 11A>G Lys4Arg
M0187156 HEOOCNGA_00096 75565 3 Gut 0.03 protein_coding synonymous_variant LOW 93A>G Lys31Lys
M0187157 HEOOCNGA_00096 75571 3 Gut 0.03 protein_coding synonymous_variant LOW 99C>T Cys33Cys
M0187158 HEOOCNGA_00096 75601 3 Gut 0.03 protein_coding synonymous_variant LOW 129G>A Lys43Lys
M0187159 HEOOCNGA_00096 75604 3 Gut 0.03 protein_coding synonymous_variant LOW 132G>A Gly44Gly
M0187160 HEOOCNGA_00096 75610 3 Gut 0.03 protein_coding synonymous_variant LOW 138C>T Cys46Cys
M0187161 HEOOCNGA_00096 75612 3 Gut 0.03 protein_coding missense_variant MODERATE 140T>G Phe47Cys
M0187162 HEOOCNGA_00096 75622 3 Gut 0.03 protein_coding missense_variant MODERATE 150T>G Asp50Glu
M0187163 HEOOCNGA_00096 75649 3 Gut 0.03 protein_coding synonymous_variant LOW 177A>G Glu59Glu
M0187164 HEOOCNGA_00096 75659 3 Gut 0.03 protein_coding missense_variant MODERATE 187A>G Asn63Asp
M0187165 HEOOCNGA_00096 75661 3 Gut 0.03 protein_coding missense_variant MODERATE 189C>G Asn63Lys
M0187166 HEOOCNGA_00096 75666 3 Gut 0.03 protein_coding missense_variant MODERATE 194A>G Lys65Arg
M0187167 HEOOCNGA_00096 75667 3 Gut 0.03 protein_coding synonymous_variant LOW 195A>G Lys65Lys
M0187168 HEOOCNGA_00096 75688 3 Gut 0.03 protein_coding missense_variant MODERATE 216C>G Asn72Lys
M0187169 HEOOCNGA_00096 75722 3 Gut 0.03 protein_coding missense_variant MODERATE 250G>A Val84Ile
M0187170 HEOOCNGA_00096 75796 3 Gut 0.03 protein_coding synonymous_variant LOW 324C>T Cys108Cys
M0187171 HEOOCNGA_00096 75800 3 Gut 0.03 protein_coding synonymous_variant LOW 328C>T Leu110Leu
M0187172 HEOOCNGA_00096 75820 3 Gut 0.03 protein_coding synonymous_variant LOW 348T>A Ala116Ala
M0187173 HEOOCNGA_00096 75868 3 Gut 0.03 protein_coding synonymous_variant LOW 396C>T Gly132Gly
M0187174 HEOOCNGA_00096 75896 3 Gut 0.03 protein_coding missense_variant MODERATE 424G>A Gly142Ser
M0187175 HEOOCNGA_00096 75943 3 Gut 0.03 protein_coding synonymous_variant LOW 471G>A Leu157Leu
M0187176 HEOOCNGA_00096 75974 3 Gut 0.03 protein_coding missense_variant MODERATE 502C>T Arg168Cys
M0187177 HEOOCNGA_00096 75983 3 Gut 0.03 protein_coding missense_variant MODERATE 511G>A Asp171Asn
M0187178 HEOOCNGA_00096 76000 3 Gut 0.03 protein_coding synonymous_variant LOW 528T>C Val176Val
M0187179 HEOOCNGA_00096 76045 3 Gut 0.03 protein_coding synonymous_variant LOW 573A>G Gly191Gly
M0187180 HEOOCNGA_00096 76056 3 Gut 0.03 protein_coding missense_variant MODERATE 584C>T Ala195Val
M0187181 HEOOCNGA_00096 76084 3 Gut 0.03 protein_coding synonymous_variant LOW 612C>T Phe204Phe
M0187182 HEOOCNGA_00096 76088 3 Gut 0.03 protein_coding missense_variant MODERATE 616A>G Met206Val
M0187183 HEOOCNGA_00096 76089 3 Gut 0.03 protein_coding missense_variant MODERATE 617T>C Met206Thr
M0187184 HEOOCNGA_00096 76180 3 Gut 0.03 protein_coding missense_variant MODERATE 708A>G Ile236Met
M0187185 HEOOCNGA_00096 76199 3 Gut 0.03 protein_coding missense_variant MODERATE 727G>A Val243Ile
M0187186 HEOOCNGA_00096 76216 3 Gut 0.03 protein_coding synonymous_variant LOW 744A>G Arg248Arg
M0187187 HEOOCNGA_00096 76276 3 Gut 0.03 protein_coding synonymous_variant LOW 804A>G Glu268Glu
M0187188 HEOOCNGA_00096 76285 3 Gut 0.03 protein_coding synonymous_variant LOW 813G>A Leu271Leu
M0187189 HEOOCNGA_00096 76294 3 Gut 0.03 protein_coding synonymous_variant LOW 822A>G Arg274Arg
M0187190 HEOOCNGA_00096 76337 3 Gut 0.03 protein_coding missense_variant MODERATE 865G>A Asp289Asn
M0187191 HEOOCNGA_00096 76560 3 Gut 0.03 protein_coding missense_variant MODERATE 1088C>T Thr363Met
M0187192 HEOOCNGA_00096 76624 3 Gut 0.03 protein_coding synonymous_variant LOW 1152T>C Cys384Cys
M0187193 HEOOCNGA_00067 62195 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -4737G>A None
M0187194 HEOOCNGA_00067 62199 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -4741C>A None
M0187195 HEOOCNGA_00067 62285 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -4827C>A None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
HEOOCNGA_00021 PHI:3281 AS87_04050 71.4 3e-136 1 325 1.0000 1.0000 birds fibrinous serositis; caseous salpingitis; vegetative disorder lipopolysaccharide biosynthesis and pathogenicity reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
HEOOCNGA_00008 QUT64421.1|GT4 100 1.11e-279 1 378 1 1
HEOOCNGA_00010 QUT55894.1|GT2 100 1.57e-228 1 304 1 1
HEOOCNGA_00013 QRP91616.1|GT4 100 5.41e-274 1 366 1 1
HEOOCNGA_00014 BBK89584.1|GT2 100 6.37e-226 1 300 1 1
HEOOCNGA_00015 QRP91614.1|GT4 100 4.79e-292 1 391 1 1
HEOOCNGA_00016 QUT83193.1|GT4 100 0 1 444 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term