Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C914
  Reference Plasmid   NZ_CP077321.1
  Reference Plasmid Size   168461
  Reference Plasmid GC Content   0.36
  Reference Plasmid Mobility Type   conjugative





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0188495 KIPGOOKF_00049 45430 3 Gut 0.17 protein_coding synonymous_variant LOW 1080A>C Ile360Ile
M0188496 KIPGOOKF_00049 46029 3 Gut 0.17 protein_coding missense_variant MODERATE 481A>G Arg161Gly
M0188497 KIPGOOKF_00003 2673 3 Gut 0.17 protein_coding missense_variant MODERATE 532A>G Arg178Gly
M0188498 KIPGOOKF_00003 3128 3 Gut 0.17 protein_coding synonymous_variant LOW 987A>T Leu329Leu
M0188499 KIPGOOKF_00003 3300 3 Gut 0.17 protein_coding missense_variant MODERATE 1159A>G Lys387Glu
M0188500 KIPGOOKF_00003 3961 3 Gut 0.17 protein_coding missense_variant MODERATE 1820G>A Ser607Asn
M0188501 KIPGOOKF_00039 34371 3 Gut 0.17 protein_coding missense_variant MODERATE 476T>C Val159Ala
M0188502 KIPGOOKF_00040 36953 3 Gut 0.17 protein_coding missense_variant MODERATE 500A>G Asp167Gly






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition
KIPGOOKF_00045 VFG042984 PilA-type pili (PGS1, pilin gene clusters 1) 99.3 0 1 696 1.0 1 Adherence minor pilin subunit prediction
KIPGOOKF_00046 VFG042985 PilA-type pili (PGS1, pilin gene clusters 1) 97.7 1.4e-37 1 86 1.0 1 Adherence hypothetical hydrophobic peptide prediction
KIPGOOKF_00047 VFG042986 PilA-type pili (PGS1, pilin gene clusters 1) 100 2.4e-133 1 251 1.0 1 Adherence cell wall-associated LPXTG-like protein prediction
KIPGOOKF_00048 VFG042987 PilA-type pili (PGS1, pilin gene clusters 1) 100 1.3e-139 1 250 1.0 1 Adherence putative pilus-dedicated sortase prediction
KIPGOOKF_00049 VFG042988 PilA-type pili (PGS1, pilin gene clusters 1) 99.5 0 1 658 1.0 1 Adherence PilA prediction
KIPGOOKF_00050 VFG042989 PilA-type pili (PGS1, pilin gene clusters 1) 100 4.2e-126 1 223 1.0 1 Adherence putative housekeeping sortase prediction
KIPGOOKF_00172 VFG042998 Bee (biofilm enhancer in enterococci) 98.4 3.7e-207 1 373 1.0 1 Adherence Srt2 prediction
KIPGOOKF_00173 VFG042997 Bee (biofilm enhancer in enterococci) 98.2 3.3e-222 1 398 1.0 1 Adherence Srt1 prediction
KIPGOOKF_00174 VFG042996 Bee (biofilm enhancer in enterococci) 98 7.1e-275 1 495 1.0 1 Adherence Bee3 prediction
KIPGOOKF_00175 VFG042995 Bee (biofilm enhancer in enterococci) 99.2 2.3e-133 1 243 1.0 1 Adherence Bee2 prediction
KIPGOOKF_00176 VFG042994 Bee (biofilm enhancer in enterococci) 98.3 0 1 1043 1.0 0.9631 Adherence Bee1 prediction







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
KIPGOOKF_00135 PHI:5205 HMPREF0351_10118 (WxL locusC) 78 8.6e-49 1 118 1.0000 1.0000 rodents endocarditis involved in bile salt stress and endocarditis pathogenesis reduced virulence
KIPGOOKF_00142 PHI:5205 HMPREF0351_10118 (WxL locusC) 74.2 8.4e-173 1 392 0.9899 1.0000 rodents endocarditis involved in bile salt stress and endocarditis pathogenesis reduced virulence
KIPGOOKF_00148 PHI:5205 HMPREF0351_10118 (WxL locusC) 99.5 5.5e-225 1 392 1.0000 1.0000 rodents endocarditis involved in bile salt stress and endocarditis pathogenesis reduced virulence
KIPGOOKF_00190 PHI:8586 mntH1 78.4 1.2e-222 21 530 0.9533 0.9586 moths nosocomial infection divalent metal cation transporter unaffected pathogenicity






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
KIPGOOKF_00034 QPQ28661.1|GH73 100 9.07e-277 1 401 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term