Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C957
  Reference Plasmid   NZ_CP084015.1
  Reference Plasmid Size   6945
  Reference Plasmid GC Content   0.36
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0191004 HLIAIAND_00004 1427 3 Gut 0.33 protein_coding missense_variant MODERATE 820A>G Ser274Gly
M0191005 HLIAIAND_00005 2980 5 Gut 0.56 protein_coding synonymous_variant LOW 396T>C Asp132Asp
M0191006 HLIAIAND_00005 3034 3 Gut 0.33 protein_coding synonymous_variant LOW 450A>G Lys150Lys
M0191007 HLIAIAND_00001 3153 4 Gut 0.44 protein_coding upstream_gene_variant MODIFIER -2793C>T None
M0191008 HLIAIAND_00001 3158 4 Gut 0.44 protein_coding upstream_gene_variant MODIFIER -2798T>G None
M0191009 HLIAIAND_00001 3161 4 Gut 0.44 protein_coding upstream_gene_variant MODIFIER -2801T>G None
M0191010 HLIAIAND_00001 3461 5 Gut 0.56 protein_coding upstream_gene_variant MODIFIER -3101A>C None
M0191011 HLIAIAND_00001 3463 5 Gut 0.56 protein_coding upstream_gene_variant MODIFIER -3103G>C None
M0191012 HLIAIAND_00001 3464 5 Gut 0.56 protein_coding upstream_gene_variant MODIFIER -3104C>G None
M0191013 HLIAIAND_00001 3465 5 Gut 0.56 protein_coding upstream_gene_variant MODIFIER -3105G>C None
M0191014 HLIAIAND_00001 3467 5 Gut 0.56 protein_coding upstream_gene_variant MODIFIER -3107G>T None
M0191015 HLIAIAND_00001 4081 4 Gut 0.44 protein_coding upstream_gene_variant MODIFIER -3721C>T None
M0191016 HLIAIAND_00001 4100 4 Gut 0.44 protein_coding upstream_gene_variant MODIFIER -3740A>T None
M0191017 HLIAIAND_00001 4209 8 Gut 0.89 protein_coding upstream_gene_variant MODIFIER -3849A>G None
M0191018 HLIAIAND_00006 4533 4 Gut 0.44 protein_coding missense_variant MODERATE 1117T>G Ser373Ala
M0191019 HLIAIAND_00006 4591 4 Gut 0.44 protein_coding missense_variant MODERATE 1059A>C Glu353Asp
M0191020 HLIAIAND_00006 4622 5 Gut 0.56 protein_coding missense_variant MODERATE 1028A>C Glu343Ala
M0191021 HLIAIAND_00006 4644 5 Gut 0.56 protein_coding missense_variant MODERATE 1006G>A Gly336Arg
M0191022 HLIAIAND_00006 4668 4 Gut 0.44 protein_coding missense_variant MODERATE 982G>A Ala328Thr
M0191023 HLIAIAND_00006 4722 4 Gut 0.44 protein_coding missense_variant MODERATE 928G>A Val310Ile
M0191024 HLIAIAND_00006 4762 4 Gut 0.44 protein_coding synonymous_variant LOW 888A>G Ala296Ala
M0191025 HLIAIAND_00006 4786 4 Gut 0.44 protein_coding missense_variant MODERATE 864A>T Glu288Asp
M0191026 HLIAIAND_00006 4806 4 Gut 0.44 protein_coding missense_variant MODERATE 844T>A Leu282Met
M0191027 HLIAIAND_00006 4810 4 Gut 0.44 protein_coding synonymous_variant LOW 840G>A Glu280Glu
M0191028 HLIAIAND_00006 4864 5 Gut 0.56 protein_coding synonymous_variant LOW 786T>C Ile262Ile
M0191029 HLIAIAND_00006 4984 7 Gut 0.78 protein_coding synonymous_variant LOW 666T>C Asp222Asp
M0191030 HLIAIAND_00006 4998 7 Gut 0.78 protein_coding missense_variant MODERATE 652A>G Asn218Asp
M0191031 HLIAIAND_00006 5023 7 Gut 0.78 protein_coding synonymous_variant LOW 627A>G Gln209Gln
M0191032 HLIAIAND_00006 5025 4 Gut 0.44 protein_coding missense_variant MODERATE 625C>G Gln209Glu
M0191033 HLIAIAND_00006 5085 6 Gut 0.67 protein_coding missense_variant MODERATE 565G>A Val189Met
M0191034 HLIAIAND_00006 5229 8 Gut 0.89 protein_coding missense_variant MODERATE 421C>A Leu141Ile
M0191035 HLIAIAND_00006 5335 4 Gut 0.44 protein_coding synonymous_variant LOW 315G>A Val105Val
M0191036 HLIAIAND_00006 5340 4 Gut 0.44 protein_coding synonymous_variant LOW 310T>C Leu104Leu
M0191037 HLIAIAND_00006 5347 4 Gut 0.44 protein_coding synonymous_variant LOW 303T>C Ser101Ser
M0191038 HLIAIAND_00006 5370 4 Gut 0.44 protein_coding missense_variant MODERATE 280A>C Asn94His
M0191039 HLIAIAND_00006 5376 8 Gut 0.89 protein_coding missense_variant MODERATE 274A>C Ile92Leu
M0191040 HLIAIAND_00006 5395 8 Gut 0.89 protein_coding synonymous_variant LOW 255T>C Ala85Ala
M0191041 HLIAIAND_00006 5422 4 Gut 0.44 protein_coding synonymous_variant LOW 228G>A Val76Val
M0191042 HLIAIAND_00006 5424 4 Gut 0.44 protein_coding missense_variant MODERATE 226G>A Val76Met
M0191043 HLIAIAND_00006 5431 4 Gut 0.44 protein_coding synonymous_variant LOW 219C>T Val73Val
M0191044 HLIAIAND_00006 5473 4 Gut 0.44 protein_coding synonymous_variant LOW 177G>A Ala59Ala
M0191045 HLIAIAND_00006 5506 4 Gut 0.44 protein_coding synonymous_variant LOW 144C>T Val48Val
M0191046 HLIAIAND_00006 5515 6 Gut 0.67 protein_coding synonymous_variant LOW 135G>A Lys45Lys
M0191047 HLIAIAND_00006 5548 6 Gut 0.67 protein_coding missense_variant MODERATE 102G>A Met34Ile
M0191048 HLIAIAND_00003 5792 7 Gut 0.78 protein_coding upstream_gene_variant MODIFIER -4793G>A None
M0191049 HLIAIAND_00007 5948 5 Gut 0.56 protein_coding synonymous_variant LOW 96G>A Glu32Glu
M0191050 HLIAIAND_00007 5969 5 Gut 0.56 protein_coding synonymous_variant LOW 117G>A Ala39Ala
M0191051 HLIAIAND_00007 5977 5 Gut 0.56 protein_coding missense_variant MODERATE 125G>A Arg42Lys
M0191052 HLIAIAND_00007 5990 5 Gut 0.56 protein_coding synonymous_variant LOW 138G>A Glu46Glu
M0191053 HLIAIAND_00007 5996 5 Gut 0.56 protein_coding synonymous_variant LOW 144A>T Gly48Gly
M0191054 HLIAIAND_00007 6002 5 Gut 0.56 protein_coding synonymous_variant LOW 150G>T Ala50Ala
M0191055 HLIAIAND_00007 6026 5 Gut 0.56 protein_coding synonymous_variant LOW 174A>G Pro58Pro
M0191056 HLIAIAND_00007 6044 7 Gut 0.78 protein_coding synonymous_variant LOW 192C>A Ile64Ile
M0191057 HLIAIAND_00007 6047 5 Gut 0.56 protein_coding synonymous_variant LOW 195A>C Pro65Pro
M0191058 HLIAIAND_00007 6083 5 Gut 0.56 protein_coding synonymous_variant LOW 231T>A Arg77Arg
M0191059 HLIAIAND_00001 4063 4 Gut 0.44 protein_coding upstream_gene_variant MODIFIER -3703A>G None
M0191060 HLIAIAND_00001 259 3 Gut 0.33 protein_coding synonymous_variant LOW 102T>C Phe34Phe
M0191061 HLIAIAND_00002 397 3 Gut 0.33 protein_coding missense_variant MODERATE 220G>A Glu74Lys
M0191062 HLIAIAND_00002 401 3 Gut 0.33 protein_coding missense_variant MODERATE 216A>G Ile72Met
M0191063 HLIAIAND_00003 5779 3 Gut 0.33 protein_coding upstream_gene_variant MODIFIER -4780C>T None
M0191064 HLIAIAND_00003 5789 3 Gut 0.33 protein_coding upstream_gene_variant MODIFIER -4790A>G None
M0191065 HLIAIAND_00003 5811 3 Gut 0.33 protein_coding upstream_gene_variant MODIFIER -4812A>C None
M0191066 HLIAIAND_00006 4909 3 Gut 0.33 protein_coding synonymous_variant LOW 741G>A Glu247Glu
M0191067 HLIAIAND_00006 4924 3 Gut 0.33 protein_coding synonymous_variant LOW 726A>G Val242Val
M0191068 HLIAIAND_00006 4942 3 Gut 0.33 protein_coding synonymous_variant LOW 708C>T Thr236Thr
M0191069 HLIAIAND_00006 5047 3 Gut 0.33 protein_coding synonymous_variant LOW 603A>G Glu201Glu
M0191070 HLIAIAND_00006 5053 3 Gut 0.33 protein_coding synonymous_variant LOW 597G>A Lys199Lys






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term