Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C968
  Reference Plasmid   NZ_CP086260.1
  Reference Plasmid Size   83340
  Reference Plasmid GC Content   0.53
  Reference Plasmid Mobility Type   conjugative





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0191367 OEPCGKAM_00059 55707 3 Gut 0.75 protein_coding synonymous_variant LOW 1608T>C Ser536Ser
M0191368 OEPCGKAM_00059 55737 3 Gut 0.75 protein_coding synonymous_variant LOW 1578T>C Leu526Leu
M0191369 OEPCGKAM_00059 56997 3 Gut 0.75 protein_coding synonymous_variant LOW 318T>C Ile106Ile
M0191370 OEPCGKAM_00059 57098 3 Gut 0.75 protein_coding synonymous_variant LOW 217T>C Leu73Leu
M0191371 OEPCGKAM_00059 57102 3 Gut 0.75 protein_coding synonymous_variant LOW 213C>A Gly71Gly
M0191372 OEPCGKAM_00059 57105 3 Gut 0.75 protein_coding synonymous_variant LOW 210T>C Val70Val
M0191373 OEPCGKAM_00065 59628 3 Gut 0.75 protein_coding synonymous_variant LOW 417G>A Ala139Ala
M0191374 OEPCGKAM_00065 59631 3 Gut 0.75 protein_coding synonymous_variant LOW 414G>A Ala138Ala
M0191375 OEPCGKAM_00065 59652 3 Gut 0.75 protein_coding synonymous_variant LOW 393T>C Pro131Pro
M0191376 OEPCGKAM_00065 59682 3 Gut 0.75 protein_coding synonymous_variant LOW 363G>A Ala121Ala
M0191377 OEPCGKAM_00065 59706 3 Gut 0.75 protein_coding synonymous_variant LOW 339T>A Thr113Thr
M0191378 OEPCGKAM_00065 59718 3 Gut 0.75 protein_coding synonymous_variant LOW 327C>T Asn109Asn
M0191379 OEPCGKAM_00065 59720 3 Gut 0.75 protein_coding missense_variant MODERATE 325A>G Asn109Asp
M0191380 OEPCGKAM_00065 59721 3 Gut 0.75 protein_coding synonymous_variant LOW 324T>G Gly108Gly
M0191381 OEPCGKAM_00065 59766 3 Gut 0.75 protein_coding synonymous_variant LOW 279T>C Thr93Thr
M0191382 OEPCGKAM_00065 59771 3 Gut 0.75 protein_coding synonymous_variant LOW 274T>C Leu92Leu
M0191383 OEPCGKAM_00065 59772 3 Gut 0.75 protein_coding synonymous_variant LOW 273T>C Ile91Ile
M0191384 OEPCGKAM_00065 59790 3 Gut 0.75 protein_coding synonymous_variant LOW 255C>T Ala85Ala
M0191385 OEPCGKAM_00065 59796 3 Gut 0.75 protein_coding synonymous_variant LOW 249C>G Val83Val
M0191386 OEPCGKAM_00065 59799 3 Gut 0.75 protein_coding synonymous_variant LOW 246G>C Thr82Thr
M0191387 OEPCGKAM_00065 59802 3 Gut 0.75 protein_coding synonymous_variant LOW 243C>T Arg81Arg
M0191388 OEPCGKAM_00065 59826 3 Gut 0.75 protein_coding synonymous_variant LOW 219T>G Val73Val
M0191389 OEPCGKAM_00065 59831 3 Gut 0.75 protein_coding missense_variant MODERATE 214C>A Leu72Met
M0191390 OEPCGKAM_00065 59832 3 Gut 0.75 protein_coding synonymous_variant LOW 213T>C His71His
M0191391 OEPCGKAM_00065 59835 3 Gut 0.75 protein_coding synonymous_variant LOW 210T>C Phe70Phe
M0191392 OEPCGKAM_00065 59850 3 Gut 0.75 protein_coding synonymous_variant LOW 195T>G Pro65Pro
M0191393 OEPCGKAM_00065 59938 3 Gut 0.75 protein_coding missense_variant MODERATE 107A>G Tyr36Cys
M0191394 OEPCGKAM_00065 59953 3 Gut 0.75 protein_coding missense_variant MODERATE 92C>T Ala31Val
M0191395 OEPCGKAM_00065 59970 3 Gut 0.75 protein_coding synonymous_variant LOW 75T>C Gly25Gly






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
OEPCGKAM_00006 SPE00673.1|GH23 100 1.33e-115 1 161 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
OEPCGKAM_00012 3.A.7.10.1 77.9 6.6e-124 1 271 0.9748 2.8021 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
OEPCGKAM_00013 3.A.7.10.1 77.8 1.7e-175 1 379 0.9921 3.9479 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
OEPCGKAM_00016 3.A.7.10.1 73.3 1.9e-40 1 116 1.0000 1.1979 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
OEPCGKAM_00018 3.A.7.10.1 74.9 1.5e-138 1 324 1.0000 3.4063 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
OEPCGKAM_00029 9.B.40.1.2 70.1 3.4e-289 1 720 0.9986 0.9678 9 Incompletely Characterized Transport Systems 9.B Putative transport proteins 9.B.40 The DotA/TraY (DotA/TraY) Family
OEPCGKAM_00032 1.E.53.1.10 97.7 9.7e-18 8 50 0.8600 1.0000 1 Channels/Pores 1.E Holins 1.E.53 The Toxic Hok/Gef Protein (Hok/Gef) Family
OEPCGKAM_00040 3.A.7.10.1 75.6 2.4e-189 1 401 0.9282 4.1771 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
OEPCGKAM_00042 3.A.7.10.1 79.7 0 1 723 0.9439 7.5313 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family