Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1034
  Reference Plasmid   NZ_CP098821.1
  Reference Plasmid Size   44396
  Reference Plasmid GC Content   0.30
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0106855 EFLHLBLD_00042 35833 10 Skin 0.24 protein_coding synonymous_variant LOW 486T>C Tyr162Tyr
M0106856 EFLHLBLD_00042 35885 7 Skin 0.17 protein_coding missense_variant MODERATE 434G>A Gly145Glu
M0106857 EFLHLBLD_00042 35914 6 Skin 0.15 protein_coding synonymous_variant LOW 405G>A Gly135Gly
M0106858 EFLHLBLD_00042 35920 5 Skin 0.12 protein_coding synonymous_variant LOW 399C>T Ile133Ile
M0106859 EFLHLBLD_00042 35923 6 Skin 0.15 protein_coding synonymous_variant LOW 396G>A Glu132Glu
M0106860 EFLHLBLD_00042 35964 5 Skin 0.12 protein_coding missense_variant MODERATE 355A>G Thr119Ala
M0106861 EFLHLBLD_00042 38657 12 Skin 0.29 protein_coding upstream_gene_variant MODIFIER -2339G>T None
M0106862 EFLHLBLD_00043 38110 7 Skin 0.17 protein_coding missense_variant MODERATE 1686G>C Lys562Asn
M0106863 EFLHLBLD_00044 38426 3 Skin 0.07 protein_coding synonymous_variant LOW 255C>T Thr85Thr
M0106864 EFLHLBLD_00044 38471 5 Skin 0.12 protein_coding synonymous_variant LOW 300G>A Leu100Leu
M0106865 EFLHLBLD_00045 39016 3 Skin 0.07 protein_coding synonymous_variant LOW 201C>A Gly67Gly
M0106866 EFLHLBLD_00042 38695 4 Skin 0.10 protein_coding upstream_gene_variant MODIFIER -2377G>A None
M0106867 EFLHLBLD_00006 4753 3 Skin 0.07 protein_coding synonymous_variant LOW 288A>G Val96Val
M0106868 EFLHLBLD_00003 4849 3 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -2492G>A None
M0106869 EFLHLBLD_00043 36749 3 Skin 0.07 protein_coding missense_variant MODERATE 325A>G Ile109Val
M0106870 EFLHLBLD_00043 36763 5 Skin 0.12 protein_coding synonymous_variant LOW 339G>A Leu113Leu
M0106871 EFLHLBLD_00043 36822 4 Skin 0.10 protein_coding missense_variant MODERATE 398G>A Arg133Lys
M0106872 EFLHLBLD_00043 36860 3 Skin 0.07 protein_coding missense_variant MODERATE 436A>G Ile146Val
M0106873 EFLHLBLD_00043 37825 3 Skin 0.07 protein_coding synonymous_variant LOW 1401C>T Asn467Asn
M0106874 EFLHLBLD_00043 38137 3 Skin 0.07 protein_coding synonymous_variant LOW 1713C>A Ile571Ile
M0106875 EFLHLBLD_00021 15117 3 Skin 0.07 protein_coding missense_variant MODERATE 211A>G Ile71Val
M0106876 EFLHLBLD_00022 15242 3 Skin 0.07 protein_coding missense_variant MODERATE 131T>C Val44Ala
M0106877 EFLHLBLD_00018 15655 3 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -3067T>G None
M0106878 EFLHLBLD_00043 37573 3 Skin 0.07 protein_coding synonymous_variant LOW 1149G>A Lys383Lys






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
EFLHLBLD_00039 Cadmium (Cd), Zinc (Zn) 89.3 5.7e-97 1 205 1.0000 1.0000 experiment
EFLHLBLD_00032 Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] 100 1.3e-104 1 190 1.0000 1.0000 prediction
EFLHLBLD_00039 Cadmium (Cd), Zinc (Zn) 98.5 1.4e-101 1 205 1.0000 1.0000 prediction






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
EFLHLBLD_00042 ARO:3008823 97.9 5e-192 1 281 1.0000 1.0000 penicillin beta-lactam BlaZ beta-lactamase antibiotic inactivation






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
EFLHLBLD_00007 PHI:6191 Lqo 81.5 1.2e-245 1 497 0.9980 1.0000 rodents skin infection; food poisoning; respiratory disease L-lactate-quinone oxidoreductases reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
EFLHLBLD_00039 2.A.77.1.1 88.8 4.8e-95 1 205 1.0000 0.9809 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.77 The Cadmium Resistance (CadD) Family