Cluster Information | Plasmid Cluster ID | C1066 |
Reference Plasmid | NZ_CP103563.1 | |
Reference Plasmid Size | 241084 | |
Reference Plasmid GC Content | 0.52 | |
Reference Plasmid Mobility Type | conjugative |
mutid | gname | pos | count | tissue | frequnt | biotype | consequence | impact | nucchange | aachange |
---|---|---|---|---|---|---|---|---|---|---|
M0195617 | GDOBIMDK_00139 | 125083 | 3 | Gut | 0.50 | protein_coding | synonymous_variant | LOW | 195T>C | Arg65Arg |
M0195618 | GDOBIMDK_00139 | 125203 | 3 | Gut | 0.50 | protein_coding | synonymous_variant | LOW | 75C>T | Gly25Gly |
M0195619 | GDOBIMDK_00140 | 125525 | 3 | Gut | 0.50 | protein_coding | missense_variant | MODERATE | 136G>A | Val46Met |
M0195620 | GDOBIMDK_00141 | 125910 | 3 | Gut | 0.50 | protein_coding | missense_variant | MODERATE | 2375G>A | Arg792Lys |
M0195621 | GDOBIMDK_00141 | 126377 | 3 | Gut | 0.50 | protein_coding | synonymous_variant | LOW | 1908T>C | Gly636Gly |
M0195622 | GDOBIMDK_00148 | 132808 | 3 | Gut | 0.50 | protein_coding | missense_variant | MODERATE | 94G>C | Val32Leu |
M0195623 | GDOBIMDK_00149 | 133013 | 3 | Gut | 0.50 | protein_coding | synonymous_variant | LOW | 222A>T | Arg74Arg |
M0195624 | GDOBIMDK_00149 | 133100 | 3 | Gut | 0.50 | protein_coding | synonymous_variant | LOW | 135A>G | Ser45Ser |
M0195625 | GDOBIMDK_00149 | 133123 | 3 | Gut | 0.50 | protein_coding | missense_variant | MODERATE | 112A>G | Ile38Val |
M0195626 | GDOBIMDK_00149 | 133133 | 3 | Gut | 0.50 | protein_coding | synonymous_variant | LOW | 102C>A | Ala34Ala |
Gene Name | vf_gene_id | vf_name | identity | evalue | qstart | qend | query_coverage | subject_coverage | vf_category | gene_description | condition |
---|---|---|---|---|---|---|---|---|---|---|---|
GDOBIMDK_00061 | VFG001827 | ShET2 | 99.7 | 7.9e-225 | 1 | 391 | 1.0 | 1 | Exotoxin | enterotoxin | experiment |
GDOBIMDK_00152 | VFG001445 | TraJ | 73.7 | 1.6e-76 | 2 | 191 | 0.8444 | 0.9453 | Invasion | unknown protein | experiment |
GDOBIMDK_00191 | VFG000908 | Alpha-Hemolysin | 98.1 | 2.9e-253 | 1 | 478 | 1.0 | 1 | Exotoxin | Hemolysin D | experiment |
GDOBIMDK_00192 | VFG000907 | Alpha-Hemolysin | 98.3 | 0 | 1 | 707 | 1.0 | 1 | Exotoxin | Hemolysin B | experiment |
GDOBIMDK_00196 | VFG000906 | Alpha-Hemolysin | 98 | 0 | 1 | 790 | 0.9394 | 0.7715 | Exotoxin | Hemolysin A | experiment |
GDOBIMDK_00197 | VFG000905 | Alpha-Hemolysin | 97.1 | 5.9e-100 | 1 | 170 | 1.0 | 1 | Exotoxin | Hemolysin C | experiment |
GDOBIMDK_00061 | VFG036084 | Enterotoxin SenB/TieB | 100 | 1.2e-224 | 1 | 391 | 1.0 | 1 | Exotoxin | enterotoxin production-related protein TieB | prediction |
GDOBIMDK_00152 | VFG001445 | TraJ | 73.7 | 1.2e-75 | 2 | 191 | 0.8444 | 0.9453 | Invasion | unknown protein | prediction |
GDOBIMDK_00191 | VFG012472 | -Hemolysin | 98.3 | 7.4e-253 | 1 | 478 | 1.0 | 1 | Exotoxin | Hemolysin D | prediction |
GDOBIMDK_00192 | VFG012478 | -Hemolysin | 98.6 | 0 | 1 | 707 | 1.0 | 1 | Exotoxin | Hemolysin B | prediction |
GDOBIMDK_00196 | VFG000906 | Alpha-Hemolysin | 98 | 0 | 1 | 790 | 0.9394 | 0.7715 | Exotoxin | Hemolysin A | prediction |
GDOBIMDK_00197 | VFG012491 | -Hemolysin | 98.2 | 4e-100 | 1 | 170 | 1.0 | 1 | Exotoxin | Hemolysin C | prediction |
Gene Name | compound | identity | evalue | qstart | qend | query_coverage | subject_coverage | group |
---|---|---|---|---|---|---|---|---|
GDOBIMDK_00203 | Mercury (Hg) | 93.8 | 4e-73 | 1 | 144 | 1.0000 | 1.0000 | experiment |
GDOBIMDK_00204 | Mercury (Hg) | 100 | 1.2e-62 | 1 | 116 | 1.0000 | 1.0000 | experiment |
GDOBIMDK_00205 | Mercury (Hg) | 90.1 | 7e-39 | 1 | 91 | 1.0000 | 1.0000 | experiment |
GDOBIMDK_00207 | Mercury (Hg) | 85.3 | 5e-268 | 1 | 564 | 1.0018 | 1.0071 | experiment |
GDOBIMDK_00208 | Mercury (Hg) | 82.6 | 1.3e-48 | 1 | 120 | 1.0083 | 1.0000 | experiment |
GDOBIMDK_00209 | Mercury (Hg) | 78.2 | 4.9e-33 | 1 | 78 | 1.0000 | 1.0000 | experiment |
GDOBIMDK_00220 | Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)] | 100 | 1.1e-60 | 1 | 115 | 1.0000 | 1.0000 | experiment |
GDOBIMDK_00203 | Mercury (Hg) | 100 | 4.3e-76 | 1 | 144 | 1.0000 | 0.7619 | prediction |
GDOBIMDK_00204 | Mercury (Hg) | 99.1 | 3.5e-60 | 1 | 116 | 1.0000 | 1.0000 | prediction |
GDOBIMDK_00205 | Mercury (Hg) | 100 | 6.3e-41 | 1 | 91 | 1.0000 | 0.8835 | prediction |
GDOBIMDK_00207 | Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] | 100 | 0 | 1 | 564 | 1.0000 | 1.0000 | prediction |
GDOBIMDK_00208 | Mercury (Hg) | 91.7 | 5.5e-53 | 1 | 120 | 1.0000 | 1.0000 | prediction |
GDOBIMDK_00209 | Mercury (Hg) | 83.3 | 2.7e-32 | 1 | 78 | 1.0000 | 1.0000 | prediction |
Gene Name | aro_accession | identity | evalue | qstart | qend | query_coverage | subject_coverage | drug_class | amr_gene_family | resistance_mechanism |
---|---|---|---|---|---|---|---|---|---|---|
GDOBIMDK_00040 | ARO:3004621 | 99 | 6.49e-211 | 1 | 286 | 1.0000 | 1.0000 | aminoglycoside antibiotic | AAC(3) | antibiotic inactivation |
GDOBIMDK_00077 | ARO:3001878 | 100 | 1.15e-202 | 1 | 291 | 1.0000 | 1.0000 | cephalosporin | CTX-M beta-lactamase | antibiotic inactivation |
GDOBIMDK_00080 | ARO:3002581 | 98 | 1.4e-140 | 2 | 199 | 0.9950 | 0.9754 | aminoglycoside antibiotic | AAC(6') | antibiotic inactivation |
GDOBIMDK_00081 | ARO:3001396 | 100 | 6.06e-199 | 16 | 291 | 0.9485 | 1.0000 | cephalosporin | OXA beta-lactamase | antibiotic inactivation |
GDOBIMDK_00087 | ARO:3000165 | 99.7 | 7.17e-278 | 1 | 390 | 0.9774 | 0.9198 | tetracycline antibiotic | major facilitator superfamily (MFS) antibiotic efflux pump | antibiotic efflux |
GDOBIMDK_00201 | ARO:3000873 | 100 | 5.12e-208 | 1 | 286 | 1.0000 | 1.0000 | monobactam | TEM beta-lactamase | antibiotic inactivation |
GDOBIMDK_00213 | ARO:3000316 | 100 | 1e-217 | 1 | 301 | 1.0000 | 1.0000 | macrolide antibiotic | macrolide phosphotransferase (MPH) | antibiotic inactivation |
GDOBIMDK_00214 | ARO:3003839 | 100 | 4.74e-272 | 1 | 412 | 1.0000 | 1.0000 | macrolide antibiotic | macrolide phosphotransferase (MPH) | antibiotic inactivation |
GDOBIMDK_00219 | ARO:3000410 | 100 | 2.94e-199 | 1 | 279 | 1.0000 | 1.0000 | sulfonamide antibiotic | sulfonamide resistant sul | antibiotic target replacement |
GDOBIMDK_00220 | ARO:3005010 | 100 | 2.01e-78 | 1 | 115 | 1.0000 | 1.0000 | disinfecting agents and antiseptics | major facilitator superfamily (MFS) antibiotic efflux pump | antibiotic efflux |
GDOBIMDK_00221 | ARO:3002602 | 100 | 5.68e-187 | 1 | 259 | 1.0000 | 1.0000 | aminoglycoside antibiotic | ANT(3'') | antibiotic inactivation |
GDOBIMDK_00222 | ARO:3002858 | 100 | 4.78e-119 | 1 | 165 | 1.0000 | 1.0000 | diaminopyrimidine antibiotic | trimethoprim resistant dihydrofolate reductase dfr | antibiotic target replacement |
GDOBIMDK_00230 | ARO:3000412 | 100 | 4.11e-186 | 1 | 271 | 1.0000 | 1.0000 | sulfonamide antibiotic | sulfonamide resistant sul | antibiotic target replacement |
GDOBIMDK_00237 | ARO:3000165 | 99.7 | 7.17e-278 | 1 | 390 | 0.9774 | 0.9198 | tetracycline antibiotic | major facilitator superfamily (MFS) antibiotic efflux pump | antibiotic efflux |
Gene Name | phi_molconn_id | host gene_name | identity | evalue | qstart | qend | query_coverage | subject_coverage | host_descripton | disease_name | function | phenotype_of_mutant |
---|---|---|---|---|---|---|---|---|---|---|---|---|
GDOBIMDK_00061 | PHI:10795 | senB | 100 | 4.2e-225 | 1 | 391 | 1.0000 | 1.0000 | primates | neonatal meningitis | enterotoxin | increased virulence (hypervirulence) |
GDOBIMDK_00062 | PHI:10794 | cjrC | 100 | 0 | 1 | 753 | 1.0000 | 1.0000 | primates | neonatal meningitis | TonB-dependent colicin J protein | increased virulence (hypervirulence) |
GDOBIMDK_00063 | PHI:10793 | cjrB | 100 | 1.7e-137 | 1 | 258 | 1.0000 | 1.0000 | primates | neonatal meningitis | colicin Js sensitivity protein | increased virulence (hypervirulence) |
GDOBIMDK_00064 | PHI:10792 | cjrA | 100 | 5.6e-166 | 1 | 291 | 1.0000 | 1.0000 | primates | neonatal meningitis | iron-regulated protein | increased virulence (hypervirulence) |
GDOBIMDK_00193 | PHI:7837 | hlyA | 95.3 | 1.9e-125 | 18 | 251 | 0.9323 | 1.0000 | rodents | neonatal meningitis | pore forming toxin alpha-hemolysin | unaffected pathogenicity |
GDOBIMDK_00196 | PHI:7837 | hlyA | 98.5 | 0 | 1 | 790 | 0.9394 | 1.0000 | rodents | neonatal meningitis | pore forming toxin alpha-hemolysin | unaffected pathogenicity |
GDOBIMDK_00223 | PHI:9804 | int | 97.3 | 1.2e-13 | 1 | 37 | 0.1098 | 1.0000 | rodents | gastroenteritis | integrase | reduced virulence |
GDOBIMDK_00256 | PHI:3317 | hsdR | 73.1 | 0 | 1 | 1038 | 1.0000 | 1.0000 | rodents | Glasser's disease | involved in pathogenicity | reduced virulence |
Gene Name | cazy_id | identity | evalue | qstart | qend | query_coverage | subject_coverage |
---|---|---|---|---|---|---|---|
GDOBIMDK_00154 | QAZ75040.1|GH23 | 100 | 4.96e-124 | 1 | 169 | 1 | 1 |
Gene Name | tcid | identity | evalue | qstart | qend | query_coverage | subject_coverage | class_field | class_term | subclass | subclass_term | family | family_term |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GDOBIMDK_00011 | 2.A.10.1.2 | 71 | 7.9e-121 | 1 | 317 | 0.9875 | 0.9664 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.10 | The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family |
GDOBIMDK_00026 | 2.A.108.2.10 | 100 | 0 | 1 | 646 | 1.0000 | 3.7341 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.108 | The Iron/Lead Transporter (ILT) Family |
GDOBIMDK_00027 | 2.A.108.2.10 | 100 | 5e-101 | 3 | 175 | 0.9886 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.108 | The Iron/Lead Transporter (ILT) Family |
GDOBIMDK_00062 | 1.B.14.7.1 | 100 | 0 | 1 | 753 | 1.0000 | 1.0000 | 1 | Channels/Pores | 1.B | β-Barrel Porins | 1.B.14 | The Outer Membrane Receptor (OMR) Family |
GDOBIMDK_00063 | 2.C.1.1.3 | 100 | 3.7e-137 | 1 | 258 | 1.0000 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.C | Ion-gradient-driven energizers | 2.C.1 | The TonB-ExbB-ExbD/TolA-TolQ-TolR Outer Membrane Receptor Energizers and Stabilizers (TonB/TolA) Family |
GDOBIMDK_00087 | 2.A.1.2.4 | 100 | 2.4e-223 | 1 | 399 | 1.0000 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.1 | The Major Facilitator Superfamily (MFS) |
GDOBIMDK_00088 | 2.A.7.3.67 | 100 | 1.8e-159 | 1 | 294 | 1.0000 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.7 | The Drug/Metabolite Transporter (DMT) Superfamily |
GDOBIMDK_00112 | 1.E.53.1.11 | 98.5 | 2.5e-32 | 1 | 68 | 1.0000 | 1.0000 | 1 | Channels/Pores | 1.E | Holins | 1.E.53 | The Toxic Hok/Gef Protein (Hok/Gef) Family |
GDOBIMDK_00191 | 8.A.1.3.1 | 96.9 | 1.8e-249 | 1 | 478 | 1.0000 | 1.0000 | 8 | Accessory Factors Involved in Transport | 8.A | Auxiliary transport proteins | 8.A.1 | The Membrane Fusion Protein (MFP) Family |
GDOBIMDK_00192 | 3.A.1.109.1 | 97.6 | 0 | 1 | 707 | 1.0000 | 1.0000 | 3 | Primary Active Transporters | 3.A | P-P-bond-hydrolysis-driven transporters | 3.A.1 | The ATP-binding Cassette (ABC) Superfamily |
GDOBIMDK_00196 | 1.C.11.1.3 | 98.5 | 0 | 1 | 790 | 0.9394 | 0.7713 | 1 | Channels/Pores | 1.C | Pore-Forming Toxins (Proteins and Peptides) | 1.C.11 | The Pore-forming RTX Toxin (RTX-toxin) Family |
GDOBIMDK_00204 | 1.A.72.3.1 | 87.9 | 3e-54 | 1 | 116 | 1.0000 | 1.2747 | 1 | Channels/Pores | 1.A | α-Type Channels | 1.A.72 | The Mercuric Ion Pore (Mer) Superfamily |
GDOBIMDK_00205 | 1.A.72.3.1 | 90.1 | 2.6e-37 | 1 | 91 | 1.0000 | 1.0000 | 1 | Channels/Pores | 1.A | α-Type Channels | 1.A.72 | The Mercuric Ion Pore (Mer) Superfamily |
GDOBIMDK_00209 | 1.A.72.5.1 | 100 | 1.8e-39 | 1 | 78 | 1.0000 | 1.0000 | 1 | Channels/Pores | 1.A | α-Type Channels | 1.A.72 | The Mercuric Ion Pore (Mer) Superfamily |
GDOBIMDK_00218 | 2.A.51.1.7 | 99.5 | 5.1e-210 | 1 | 376 | 0.9377 | 0.9666 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.51 | The Chromate Ion Transporter (CHR) Family |
GDOBIMDK_00237 | 2.A.1.2.4 | 100 | 2.4e-223 | 1 | 399 | 1.0000 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.1 | The Major Facilitator Superfamily (MFS) |
GDOBIMDK_00238 | 2.A.7.3.67 | 100 | 1.8e-159 | 1 | 294 | 1.0000 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.7 | The Drug/Metabolite Transporter (DMT) Superfamily |
GDOBIMDK_00266 | 2.A.3.1.10 | 99.6 | 5e-265 | 9 | 475 | 0.9832 | 1.0000 | 2 | Electrochemical Potential-driven Transporters | 2.A | Porters (uniporters, symporters, antiporters) | 2.A.3 | The Amino Acid-Polyamine-Organocation (APC) Family |