Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1118
  Reference Plasmid   NZ_CP117412.1
  Reference Plasmid Size   185404
  Reference Plasmid GC Content   0.65
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0109212 LACKECPC_00048 44372 5 Skin 0.08 protein_coding missense_variant MODERATE 1522A>G Ser508Gly
M0109213 LACKECPC_00052 49341 3 Skin 0.05 protein_coding synonymous_variant LOW 219G>T Arg73Arg
M0109214 LACKECPC_00152 141632 3 Skin 0.05 protein_coding missense_variant MODERATE 8C>T Thr3Ile
M0109215 LACKECPC_00144 141659 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -4766G>A None
M0109216 LACKECPC_00153 142248 3 Skin 0.05 protein_coding synonymous_variant LOW 528G>A Gln176Gln
M0109217 LACKECPC_00153 142476 3 Skin 0.05 protein_coding synonymous_variant LOW 756C>G Leu252Leu
M0109218 LACKECPC_00048 45173 3 Skin 0.05 protein_coding missense_variant MODERATE 721G>C Gly241Arg
M0109219 LACKECPC_00045 45971 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -4426T>C None
M0109220 LACKECPC_00126 119801 3 Skin 0.05 protein_coding synonymous_variant LOW 57C>T Pro19Pro
M0109221 LACKECPC_00126 119848 3 Skin 0.05 protein_coding missense_variant MODERATE 10C>G Leu4Val
M0109222 LACKECPC_00127 119875 3 Skin 0.05 protein_coding synonymous_variant LOW 1008G>A Pro336Pro
M0109223 LACKECPC_00127 120361 4 Skin 0.06 protein_coding synonymous_variant LOW 522A>G Glu174Glu
M0109224 LACKECPC_00064 59278 5 Skin 0.08 protein_coding synonymous_variant LOW 255C>G Thr85Thr
M0109225 LACKECPC_00064 59317 5 Skin 0.08 protein_coding synonymous_variant LOW 294T>C Asp98Asp
M0109226 LACKECPC_00064 59374 5 Skin 0.08 protein_coding synonymous_variant LOW 351T>C Asn117Asn
M0109227 LACKECPC_00064 59377 4 Skin 0.06 protein_coding synonymous_variant LOW 354G>A Arg118Arg
M0109228 LACKECPC_00064 59398 5 Skin 0.08 protein_coding synonymous_variant LOW 375T>C Ala125Ala
M0109229 LACKECPC_00064 59437 5 Skin 0.08 protein_coding synonymous_variant LOW 414G>C Val138Val
M0109230 LACKECPC_00064 59443 5 Skin 0.08 protein_coding synonymous_variant LOW 420G>A Gln140Gln
M0109231 LACKECPC_00064 59452 5 Skin 0.08 protein_coding synonymous_variant LOW 429C>A Gly143Gly
M0109232 LACKECPC_00064 59461 5 Skin 0.08 protein_coding synonymous_variant LOW 438A>T Arg146Arg
M0109233 LACKECPC_00064 59476 5 Skin 0.08 protein_coding synonymous_variant LOW 453G>A Pro151Pro
M0109234 LACKECPC_00064 59479 5 Skin 0.08 protein_coding synonymous_variant LOW 456C>T Arg152Arg
M0109235 LACKECPC_00064 59482 5 Skin 0.08 protein_coding synonymous_variant LOW 459C>T Val153Val
M0109236 LACKECPC_00064 59503 5 Skin 0.08 protein_coding synonymous_variant LOW 480T>C Asn160Asn
M0109237 LACKECPC_00064 59518 5 Skin 0.08 protein_coding synonymous_variant LOW 495C>T Asn165Asn
M0109238 LACKECPC_00064 59524 5 Skin 0.08 protein_coding synonymous_variant LOW 501G>A Lys167Lys
M0109239 LACKECPC_00064 59573 5 Skin 0.08 protein_coding missense_variant MODERATE 550G>A Ala184Thr
M0109240 LACKECPC_00064 59599 5 Skin 0.08 protein_coding synonymous_variant LOW 576C>T Gly192Gly
M0109241 LACKECPC_00064 59602 5 Skin 0.08 protein_coding synonymous_variant LOW 579T>G Ala193Ala
M0109242 LACKECPC_00064 59611 5 Skin 0.08 protein_coding synonymous_variant LOW 588G>A Gln196Gln
M0109243 LACKECPC_00064 59770 5 Skin 0.08 protein_coding synonymous_variant LOW 747C>T Tyr249Tyr
M0109244 LACKECPC_00064 59926 5 Skin 0.08 protein_coding synonymous_variant LOW 903T>C Arg301Arg
M0109245 LACKECPC_00064 59953 5 Skin 0.08 protein_coding synonymous_variant LOW 930T>C Gly310Gly
M0109246 LACKECPC_00064 59957 5 Skin 0.08 protein_coding missense_variant MODERATE 934G>A Ala312Thr
M0109247 LACKECPC_00064 59962 5 Skin 0.08 protein_coding synonymous_variant LOW 939C>A Ile313Ile
M0109248 LACKECPC_00064 59971 5 Skin 0.08 protein_coding synonymous_variant LOW 948A>G Glu316Glu
M0109249 LACKECPC_00064 59974 5 Skin 0.08 protein_coding synonymous_variant LOW 951G>A Ala317Ala
M0109250 LACKECPC_00064 59992 5 Skin 0.08 protein_coding synonymous_variant LOW 969G>C Gly323Gly
M0109251 LACKECPC_00064 60046 5 Skin 0.08 protein_coding synonymous_variant LOW 1023T>A Gly341Gly
M0109252 LACKECPC_00061 60772 4 Skin 0.06 protein_coding upstream_gene_variant MODIFIER -4005A>G None
M0109253 LACKECPC_00064 59100 3 Skin 0.05 protein_coding missense_variant MODERATE 77T>C Val26Ala
M0109254 LACKECPC_00064 59119 3 Skin 0.05 protein_coding synonymous_variant LOW 96T>G Pro32Pro
M0109255 LACKECPC_00064 59122 3 Skin 0.05 protein_coding synonymous_variant LOW 99G>A Ala33Ala
M0109256 LACKECPC_00064 59155 4 Skin 0.06 protein_coding synonymous_variant LOW 132C>T Pro44Pro
M0109257 LACKECPC_00064 59200 4 Skin 0.06 protein_coding synonymous_variant LOW 177A>G Lys59Lys
M0109258 LACKECPC_00064 59215 4 Skin 0.06 protein_coding synonymous_variant LOW 192T>C Leu64Leu
M0109259 LACKECPC_00064 59221 4 Skin 0.06 protein_coding synonymous_variant LOW 198C>T Arg66Arg
M0109260 LACKECPC_00064 59233 4 Skin 0.06 protein_coding synonymous_variant LOW 210T>C Pro70Pro
M0109261 LACKECPC_00064 59242 4 Skin 0.06 protein_coding synonymous_variant LOW 219G>A Glu73Glu
M0109262 LACKECPC_00064 59254 4 Skin 0.06 protein_coding missense_variant MODERATE 231G>C Glu77Asp
M0109263 LACKECPC_00065 60301 4 Skin 0.06 protein_coding synonymous_variant LOW 30C>T Ala10Ala
M0109264 LACKECPC_00065 60567 3 Skin 0.05 protein_coding missense_variant MODERATE 296C>T Ala99Val
M0109265 LACKECPC_00065 60571 3 Skin 0.05 protein_coding synonymous_variant LOW 300C>T Asp100Asp
M0109266 LACKECPC_00065 60628 3 Skin 0.05 protein_coding synonymous_variant LOW 357G>A Glu119Glu
M0109267 LACKECPC_00065 60637 3 Skin 0.05 protein_coding synonymous_variant LOW 366T>C Val122Val
M0109268 LACKECPC_00065 60660 3 Skin 0.05 protein_coding missense_variant MODERATE 389C>T Thr130Ile
M0109269 LACKECPC_00161 149113 3 Skin 0.05 protein_coding missense_variant MODERATE 235T>C Tyr79His
M0109270 LACKECPC_00157 149659 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -2894T>C None
M0109271 LACKECPC_00157 149722 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -2957C>G None
M0109272 LACKECPC_00157 149724 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -2959C>G None
M0109273 LACKECPC_00157 149769 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -3004G>T None
M0109274 LACKECPC_00163 150036 3 Skin 0.05 protein_coding synonymous_variant LOW 195G>C Leu65Leu
M0109275 LACKECPC_00128 121312 4 Skin 0.06 protein_coding missense_variant MODERATE 968T>C Val323Ala
M0109276 LACKECPC_00128 122166 4 Skin 0.06 protein_coding synonymous_variant LOW 114A>G Arg38Arg
M0109277 LACKECPC_00129 122468 5 Skin 0.08 protein_coding missense_variant MODERATE 1138A>G Ile380Val
M0109278 LACKECPC_00129 122727 5 Skin 0.08 protein_coding synonymous_variant LOW 879T>G Val293Val
M0109279 LACKECPC_00130 123745 5 Skin 0.08 protein_coding missense_variant MODERATE 307A>G Ser103Gly
M0109280 LACKECPC_00131 124337 5 Skin 0.08 protein_coding missense_variant MODERATE 1090A>G Asn364Asp
M0109281 LACKECPC_00131 125199 4 Skin 0.06 protein_coding synonymous_variant LOW 228T>C Gly76Gly
M0109282 LACKECPC_00132 125462 5 Skin 0.08 protein_coding synonymous_variant LOW 660G>C Ser220Ser
M0109283 LACKECPC_00009 12460 4 Skin 0.06 protein_coding upstream_gene_variant MODIFIER -3789A>G None
M0109284 LACKECPC_00043 39267 5 Skin 0.08 protein_coding synonymous_variant LOW 414A>G Ala138Ala
M0109285 LACKECPC_00057 53802 4 Skin 0.06 protein_coding synonymous_variant LOW 1371G>C Arg457Arg
M0109286 LACKECPC_00041 37428 4 Skin 0.06 protein_coding missense_variant MODERATE 240T>G Ile80Met
M0109287 LACKECPC_00042 37838 3 Skin 0.05 protein_coding missense_variant MODERATE 55C>T His19Tyr
M0109288 LACKECPC_00041 37008 3 Skin 0.05 protein_coding synonymous_variant LOW 660C>T Phe220Phe
M0109289 LACKECPC_00041 37602 3 Skin 0.05 protein_coding synonymous_variant LOW 66C>T Asp22Asp
M0109290 LACKECPC_00128 121624 3 Skin 0.05 protein_coding missense_variant MODERATE 656C>G Thr219Ser






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
LACKECPC_00017 Copper (Cu) 76.9 1e-127 1 308 1.0000 1.0000 prediction
LACKECPC_00018 Copper (Cu) 82 2.1e-47 1 122 1.0000 1.0000 prediction
LACKECPC_00176 Arsenic (As) 74.8 2e-89 12 230 0.8845 0.9328 prediction






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
LACKECPC_00037 WCT75647.1|GH13 99.3 3.76e-107 69 218 0.6881 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
LACKECPC_00044 9.B.72.1.6 73.3 1.6e-42 1 116 1.0000 1.0000 9 Incompletely Characterized Transport Systems 9.B Putative transport proteins 9.B.72 The 4 TMS GlpM (GlpM) Family