Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1375
  Reference Plasmid   NZ_MH229772.1
  Reference Plasmid Size   6961
  Reference Plasmid GC Content   0.49
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0208489 KEPCPOJA_00001 27 12 Gut 0.10 protein_coding downstream_gene_variant MODIFIER *19A>G None
M0208490 KEPCPOJA_00001 303 10 Gut 0.08 protein_coding synonymous_variant LOW 1195A>C Arg399Arg
M0208491 KEPCPOJA_00001 661 12 Gut 0.10 protein_coding synonymous_variant LOW 837T>C Asp279Asp
M0208492 KEPCPOJA_00001 673 12 Gut 0.10 protein_coding synonymous_variant LOW 825C>T Arg275Arg
M0208493 KEPCPOJA_00001 804 9 Gut 0.08 protein_coding missense_variant MODERATE 694G>T Ala232Ser
M0208494 KEPCPOJA_00001 841 7 Gut 0.06 protein_coding synonymous_variant LOW 657C>T Phe219Phe
M0208495 KEPCPOJA_00001 957 9 Gut 0.08 protein_coding missense_variant MODERATE 541C>A Leu181Ile
M0208496 KEPCPOJA_00001 985 8 Gut 0.07 protein_coding synonymous_variant LOW 513A>G Lys171Lys
M0208497 KEPCPOJA_00001 988 9 Gut 0.08 protein_coding synonymous_variant LOW 510T>C Leu170Leu
M0208498 KEPCPOJA_00001 1159 10 Gut 0.08 protein_coding synonymous_variant LOW 339T>C Asp113Asp
M0208499 KEPCPOJA_00001 1348 89 Gut 0.75 protein_coding synonymous_variant LOW 150C>G Leu50Leu
M0208500 KEPCPOJA_00001 1435 9 Gut 0.08 protein_coding synonymous_variant LOW 63C>T Gly21Gly
M0208501 KEPCPOJA_00001 1558 7 Gut 0.06 protein_coding upstream_gene_variant MODIFIER -61C>T None
M0208502 KEPCPOJA_00001 1715 11 Gut 0.09 protein_coding upstream_gene_variant MODIFIER -218T>C None
M0208503 KEPCPOJA_00001 1757 32 Gut 0.27 protein_coding upstream_gene_variant MODIFIER -260G>A None
M0208504 KEPCPOJA_00001 1791 32 Gut 0.27 protein_coding upstream_gene_variant MODIFIER -294T>C None
M0208505 KEPCPOJA_00001 1800 8 Gut 0.07 protein_coding upstream_gene_variant MODIFIER -303C>A None
M0208506 KEPCPOJA_00001 1801 8 Gut 0.07 protein_coding upstream_gene_variant MODIFIER -304C>A None
M0208507 KEPCPOJA_00001 1804 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -307C>A None
M0208508 KEPCPOJA_00001 1805 82 Gut 0.69 protein_coding upstream_gene_variant MODIFIER -308T>C None
M0208509 KEPCPOJA_00001 1885 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -388T>G None
M0208510 KEPCPOJA_00002 1946 8 Gut 0.07 protein_coding synonymous_variant LOW 1215G>A Gln405Gln
M0208511 KEPCPOJA_00002 1970 19 Gut 0.16 protein_coding synonymous_variant LOW 1191T>C Ile397Ile
M0208512 KEPCPOJA_00002 2636 3 Gut 0.03 protein_coding synonymous_variant LOW 525C>T Gly175Gly
M0208513 KEPCPOJA_00002 2650 83 Gut 0.70 protein_coding missense_variant MODERATE 511G>T Val171Phe
M0208514 KEPCPOJA_00001 3421 19 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -1924G>T None
M0208515 KEPCPOJA_00001 40 10 Gut 0.08 protein_coding downstream_gene_variant MODIFIER *6C>A None
M0208516 KEPCPOJA_00001 1651 16 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -154C>A None
M0208517 KEPCPOJA_00005 5714 7 Gut 0.06 protein_coding missense_variant MODERATE 467G>A Arg156Lys
M0208518 KEPCPOJA_00005 5775 12 Gut 0.10 protein_coding missense_variant MODERATE 406T>G Ser136Ala
M0208519 KEPCPOJA_00005 5803 19 Gut 0.16 protein_coding synonymous_variant LOW 378A>G Thr126Thr
M0208520 KEPCPOJA_00005 5999 14 Gut 0.12 protein_coding missense_variant MODERATE 182A>C Gln61Pro
M0208521 KEPCPOJA_00001 6204 18 Gut 0.15 protein_coding upstream_gene_variant MODIFIER -4707C>T None
M0208522 KEPCPOJA_00006 6349 4 Gut 0.03 protein_coding synonymous_variant LOW 144T>C Ala48Ala
M0208523 KEPCPOJA_00002 6874 26 Gut 0.22 protein_coding upstream_gene_variant MODIFIER -3714G>C None
M0208524 KEPCPOJA_00007 6605 3 Gut 0.03 protein_coding synonymous_variant LOW 147A>G Glu49Glu
M0208525 KEPCPOJA_00007 6650 4 Gut 0.03 protein_coding synonymous_variant LOW 102T>C Gly34Gly
M0208526 KEPCPOJA_00001 1257 4 Gut 0.03 protein_coding missense_variant MODERATE 241G>A Gly81Arg
M0208527 KEPCPOJA_00001 1295 3 Gut 0.03 protein_coding missense_variant MODERATE 203A>G Asn68Ser
M0208528 KEPCPOJA_00001 619 4 Gut 0.03 protein_coding synonymous_variant LOW 879C>T Tyr293Tyr
M0208529 KEPCPOJA_00001 1642 4 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -145G>A None
M0208530 KEPCPOJA_00002 1953 3 Gut 0.03 protein_coding missense_variant MODERATE 1208A>G Gln403Arg
M0208531 KEPCPOJA_00002 2162 4 Gut 0.03 protein_coding synonymous_variant LOW 999G>A Arg333Arg
M0208532 KEPCPOJA_00002 2370 4 Gut 0.03 protein_coding missense_variant MODERATE 791C>T Ala264Val
M0208533 KEPCPOJA_00002 3140 4 Gut 0.03 protein_coding synonymous_variant LOW 21T>C Gly7Gly
M0208534 KEPCPOJA_00001 3279 4 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -1782T>C None
M0208535 KEPCPOJA_00005 5753 4 Gut 0.03 protein_coding missense_variant MODERATE 428G>A Arg143His
M0208536 KEPCPOJA_00005 5827 3 Gut 0.03 protein_coding synonymous_variant LOW 354G>A Ala118Ala
M0208537 KEPCPOJA_00005 6142 3 Gut 0.03 protein_coding synonymous_variant LOW 39C>T Gly13Gly
M0208538 KEPCPOJA_00002 6910 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -3750C>T None
M0208539 KEPCPOJA_00001 1623 4 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -126T>A None
M0208540 KEPCPOJA_00001 797 4 Gut 0.03 protein_coding missense_variant MODERATE 701C>T Ala234Val
M0208541 KEPCPOJA_00001 1339 3 Gut 0.03 protein_coding synonymous_variant LOW 159C>T Asp53Asp
M0208542 KEPCPOJA_00001 3463 13 Gut 0.11 protein_coding upstream_gene_variant MODIFIER -1966T>C None
M0208543 KEPCPOJA_00001 5678 12 Gut 0.10 protein_coding upstream_gene_variant MODIFIER -4181G>T None
M0208544 KEPCPOJA_00001 1725 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -228T>A None
M0208545 KEPCPOJA_00001 120 3 Gut 0.03 protein_coding missense_variant MODERATE 1378C>A His460Asn
M0208546 KEPCPOJA_00001 1393 3 Gut 0.03 protein_coding synonymous_variant LOW 105C>T Ser35Ser
M0208547 KEPCPOJA_00001 1718 4 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -221C>T None
M0208548 KEPCPOJA_00002 2513 4 Gut 0.03 protein_coding synonymous_variant LOW 648G>A Pro216Pro
M0208549 KEPCPOJA_00002 2876 3 Gut 0.03 protein_coding missense_variant MODERATE 285C>A Ser95Arg
M0208550 KEPCPOJA_00001 1682 4 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -185C>A None
M0208551 KEPCPOJA_00002 6798 3 Gut 0.03 protein_coding upstream_gene_variant MODIFIER -3638A>G None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
KEPCPOJA_00004 ARO:3002647 100 1.07e-198 1 264 1.0000 1.0000 aminoglycoside antibiotic APH(3') antibiotic inactivation






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term