Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1393
  Reference Plasmid   NZ_MW367470.1
  Reference Plasmid Size   10822
  Reference Plasmid GC Content   0.30
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0116691 HEKNEDPL_00003 1876 28 Skin 0.97 protein_coding missense_variant MODERATE 358A>G Thr120Ala
M0116692 HEKNEDPL_00003 2085 14 Skin 0.48 protein_coding synonymous_variant LOW 567T>G Ala189Ala
M0116693 HEKNEDPL_00003 2175 27 Skin 0.93 protein_coding synonymous_variant LOW 657T>C Ser219Ser
M0116694 HEKNEDPL_00003 2421 26 Skin 0.90 protein_coding synonymous_variant LOW 903G>A Val301Val
M0116695 HEKNEDPL_00003 2450 19 Skin 0.66 protein_coding missense_variant MODERATE 932G>T Ser311Ile
M0116696 HEKNEDPL_00003 2466 12 Skin 0.41 protein_coding synonymous_variant LOW 948T>G Ser316Ser
M0116697 HEKNEDPL_00003 2676 27 Skin 0.93 protein_coding synonymous_variant LOW 1158C>T Asp386Asp
M0116698 HEKNEDPL_00003 2853 26 Skin 0.90 protein_coding synonymous_variant LOW 1335C>T Asn445Asn
M0116699 HEKNEDPL_00003 3189 14 Skin 0.48 protein_coding synonymous_variant LOW 1671C>T His557His
M0116700 HEKNEDPL_00003 3240 11 Skin 0.38 protein_coding synonymous_variant LOW 1722T>C Ser574Ser
M0116701 HEKNEDPL_00003 3241 14 Skin 0.48 protein_coding missense_variant MODERATE 1723G>A Asp575Asn
M0116702 HEKNEDPL_00003 3291 12 Skin 0.41 protein_coding synonymous_variant LOW 1773T>C Ser591Ser
M0116703 HEKNEDPL_00003 3303 22 Skin 0.76 protein_coding synonymous_variant LOW 1785G>C Ala595Ala
M0116704 HEKNEDPL_00003 3330 22 Skin 0.76 protein_coding synonymous_variant LOW 1812T>C Gly604Gly
M0116705 HEKNEDPL_00003 3435 9 Skin 0.31 protein_coding synonymous_variant LOW 1917G>T Val639Val
M0116706 HEKNEDPL_00003 2070 7 Skin 0.24 protein_coding synonymous_variant LOW 552G>A Leu184Leu
M0116707 HEKNEDPL_00003 1707 6 Skin 0.21 protein_coding synonymous_variant LOW 189T>C Leu63Leu
M0116708 HEKNEDPL_00003 1887 15 Skin 0.52 protein_coding synonymous_variant LOW 369C>T Ile123Ile
M0116709 HEKNEDPL_00003 2331 7 Skin 0.24 protein_coding synonymous_variant LOW 813G>T Val271Val
M0116710 HEKNEDPL_00003 2509 3 Skin 0.10 protein_coding synonymous_variant LOW 991T>C Leu331Leu
M0116711 HEKNEDPL_00003 2511 3 Skin 0.10 protein_coding missense_variant MODERATE 993A>C Leu331Phe
M0116712 HEKNEDPL_00003 3390 3 Skin 0.10 protein_coding synonymous_variant LOW 1872C>T Ile624Ile
M0116713 HEKNEDPL_00003 1717 8 Skin 0.28 protein_coding synonymous_variant LOW 199C>T Leu67Leu
M0116714 HEKNEDPL_00003 1846 4 Skin 0.14 protein_coding missense_variant MODERATE 328A>G Thr110Ala
M0116715 HEKNEDPL_00003 1878 11 Skin 0.38 protein_coding synonymous_variant LOW 360C>T Thr120Thr
M0116716 HEKNEDPL_00003 1783 3 Skin 0.10 protein_coding missense_variant MODERATE 265A>G Ser89Gly
M0116717 HEKNEDPL_00003 1788 3 Skin 0.10 protein_coding synonymous_variant LOW 270A>C Thr90Thr
M0116718 HEKNEDPL_00003 3085 3 Skin 0.10 protein_coding missense_variant MODERATE 1567G>A Val523Ile
M0116719 HEKNEDPL_00003 3405 5 Skin 0.17 protein_coding synonymous_variant LOW 1887C>T Thr629Thr
M0116720 HEKNEDPL_00003 1566 4 Skin 0.14 protein_coding synonymous_variant LOW 48A>G Leu16Leu
M0116721 HEKNEDPL_00003 3186 4 Skin 0.14 protein_coding synonymous_variant LOW 1668C>T Val556Val
M0116722 HEKNEDPL_00003 3489 6 Skin 0.21 protein_coding synonymous_variant LOW 1971T>C Ala657Ala
M0116723 HEKNEDPL_00003 3493 6 Skin 0.21 protein_coding missense_variant MODERATE 1975A>G Ile659Val
M0116724 HEKNEDPL_00003 3534 6 Skin 0.21 protein_coding synonymous_variant LOW 2016T>G Gly672Gly
M0116725 HEKNEDPL_00003 3549 8 Skin 0.28 protein_coding synonymous_variant LOW 2031T>A Ser677Ser
M0116726 HEKNEDPL_00003 3558 8 Skin 0.28 protein_coding synonymous_variant LOW 2040A>G Thr680Thr
M0116727 HEKNEDPL_00003 3579 9 Skin 0.31 protein_coding synonymous_variant LOW 2061A>T Ala687Ala
M0116728 HEKNEDPL_00003 3009 8 Skin 0.28 protein_coding synonymous_variant LOW 1491T>C Ser497Ser
M0116729 HEKNEDPL_00003 3507 5 Skin 0.17 protein_coding synonymous_variant LOW 1989T>C Ile663Ile
M0116730 HEKNEDPL_00003 3559 3 Skin 0.10 protein_coding missense_variant MODERATE 2041A>G Ile681Val






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
HEKNEDPL_00008 Cadmium (Cd), Zinc (Zn) 89.8 2.2e-96 1 205 1.0000 1.0000 experiment
HEKNEDPL_00003 Copper (Cu) 95.9 0 21 693 0.9913 1.0000 prediction
HEKNEDPL_00008 Cadmium (Cd), Zinc (Zn) 99.5 6.5e-102 1 205 1.0000 1.0000 prediction






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
HEKNEDPL_00008 2.A.77.1.1 89.3 1.8e-94 1 205 1.0000 0.9809 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.77 The Cadmium Resistance (CadD) Family