Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1426
  Reference Plasmid   NZ_OY725736.1
  Reference Plasmid Size   517814
  Reference Plasmid GC Content   0.37
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0210156 DIMEDMDJ_00361 439993 4 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -41C>T None
M0210157 DIMEDMDJ_00361 440002 4 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -32A>G None
M0210158 DIMEDMDJ_00361 440132 3 Gut 0.10 protein_coding synonymous_variant LOW 99A>T Gly33Gly
M0210159 DIMEDMDJ_00361 440152 5 Gut 0.17 protein_coding missense_variant MODERATE 119G>A Arg40Lys
M0210160 DIMEDMDJ_00361 440180 3 Gut 0.10 protein_coding synonymous_variant LOW 147T>C Asp49Asp
M0210161 DIMEDMDJ_00361 440213 3 Gut 0.10 protein_coding synonymous_variant LOW 180C>T Ser60Ser
M0210162 DIMEDMDJ_00361 440285 5 Gut 0.17 protein_coding synonymous_variant LOW 252C>T Leu84Leu
M0210163 DIMEDMDJ_00362 440389 3 Gut 0.10 protein_coding synonymous_variant LOW 24G>T Ser8Ser
M0210164 DIMEDMDJ_00362 440452 4 Gut 0.14 protein_coding synonymous_variant LOW 87C>T Asp29Asp
M0210165 DIMEDMDJ_00362 440530 4 Gut 0.14 protein_coding synonymous_variant LOW 165G>A Glu55Glu
M0210166 DIMEDMDJ_00362 440539 7 Gut 0.24 protein_coding synonymous_variant LOW 174A>T Val58Val
M0210167 DIMEDMDJ_00362 440582 6 Gut 0.21 protein_coding missense_variant MODERATE 217A>G Ile73Val
M0210168 DIMEDMDJ_00362 440584 3 Gut 0.10 protein_coding synonymous_variant LOW 219A>T Ile73Ile
M0210169 DIMEDMDJ_00362 440590 8 Gut 0.28 protein_coding synonymous_variant LOW 225A>G Val75Val
M0210170 DIMEDMDJ_00362 440620 4 Gut 0.14 protein_coding synonymous_variant LOW 255T>A Ile85Ile
M0210171 DIMEDMDJ_00362 440707 4 Gut 0.14 protein_coding synonymous_variant LOW 342A>G Glu114Glu
M0210172 DIMEDMDJ_00362 440758 8 Gut 0.28 protein_coding synonymous_variant LOW 393A>G Lys131Lys
M0210173 DIMEDMDJ_00362 440770 8 Gut 0.28 protein_coding synonymous_variant LOW 405T>C Cys135Cys
M0210174 DIMEDMDJ_00362 440773 8 Gut 0.28 protein_coding synonymous_variant LOW 408T>C His136His
M0210175 DIMEDMDJ_00362 440782 8 Gut 0.28 protein_coding synonymous_variant LOW 417A>C Ile139Ile
M0210176 DIMEDMDJ_00362 440824 7 Gut 0.24 protein_coding synonymous_variant LOW 459C>T Asp153Asp
M0210177 DIMEDMDJ_00362 440845 5 Gut 0.17 protein_coding synonymous_variant LOW 480T>C Phe160Phe
M0210178 DIMEDMDJ_00362 440848 7 Gut 0.24 protein_coding synonymous_variant LOW 483T>C Arg161Arg
M0210179 DIMEDMDJ_00362 440861 8 Gut 0.28 protein_coding missense_variant MODERATE 496T>C Cys166Arg
M0210180 DIMEDMDJ_00362 440863 8 Gut 0.28 protein_coding stop_gained HIGH 498C>A Cys166*
M0210181 DIMEDMDJ_00362 440866 8 Gut 0.28 protein_coding synonymous_variant LOW 501T>G Leu167Leu
M0210182 DIMEDMDJ_00362 440896 3 Gut 0.10 protein_coding synonymous_variant LOW 531G>A Pro177Pro
M0210183 DIMEDMDJ_00362 440902 6 Gut 0.21 protein_coding synonymous_variant LOW 537A>G Pro179Pro
M0210184 DIMEDMDJ_00362 440941 5 Gut 0.17 protein_coding synonymous_variant LOW 576A>G Glu192Glu
M0210185 DIMEDMDJ_00362 440965 6 Gut 0.21 protein_coding synonymous_variant LOW 600T>C Tyr200Tyr
M0210186 DIMEDMDJ_00362 440968 6 Gut 0.21 protein_coding synonymous_variant LOW 603A>C Ser201Ser
M0210187 DIMEDMDJ_00362 440971 6 Gut 0.21 protein_coding missense_variant MODERATE 606G>T Met202Ile
M0210188 DIMEDMDJ_00362 441037 6 Gut 0.21 protein_coding synonymous_variant LOW 672G>C Leu224Leu
M0210189 DIMEDMDJ_00362 441040 8 Gut 0.28 protein_coding synonymous_variant LOW 675T>G Thr225Thr
M0210190 DIMEDMDJ_00362 441055 8 Gut 0.28 protein_coding synonymous_variant LOW 690A>G Glu230Glu
M0210191 DIMEDMDJ_00362 441094 8 Gut 0.28 protein_coding synonymous_variant LOW 729C>T Val243Val
M0210192 DIMEDMDJ_00362 441193 7 Gut 0.24 protein_coding synonymous_variant LOW 828T>C Leu276Leu
M0210193 DIMEDMDJ_00362 441229 7 Gut 0.24 protein_coding synonymous_variant LOW 864G>A Arg288Arg
M0210194 DIMEDMDJ_00362 441239 7 Gut 0.24 protein_coding missense_variant MODERATE 874A>T Met292Leu
M0210195 DIMEDMDJ_00362 441260 7 Gut 0.24 protein_coding missense_variant MODERATE 895G>A Val299Ile
M0210196 DIMEDMDJ_00362 441391 3 Gut 0.10 protein_coding synonymous_variant LOW 1026C>T Asp342Asp
M0210197 DIMEDMDJ_00362 441616 3 Gut 0.10 protein_coding synonymous_variant LOW 1251C>A Val417Val
M0210198 DIMEDMDJ_00362 441652 6 Gut 0.21 protein_coding synonymous_variant LOW 1287T>C Val429Val
M0210199 DIMEDMDJ_00363 441770 5 Gut 0.17 protein_coding synonymous_variant LOW 51A>G Glu17Glu
M0210200 DIMEDMDJ_00363 441809 3 Gut 0.10 protein_coding synonymous_variant LOW 90A>T Ala30Ala
M0210201 DIMEDMDJ_00363 441812 3 Gut 0.10 protein_coding synonymous_variant LOW 93G>A Lys31Lys
M0210202 DIMEDMDJ_00363 441881 4 Gut 0.14 protein_coding synonymous_variant LOW 162T>C Thr54Thr
M0210203 DIMEDMDJ_00363 442019 5 Gut 0.17 protein_coding synonymous_variant LOW 300C>A Val100Val
M0210204 DIMEDMDJ_00363 442358 4 Gut 0.14 protein_coding synonymous_variant LOW 639A>G Val213Val
M0210205 DIMEDMDJ_00363 442379 3 Gut 0.10 protein_coding synonymous_variant LOW 660T>C Tyr220Tyr
M0210206 DIMEDMDJ_00363 442442 4 Gut 0.14 protein_coding synonymous_variant LOW 723A>G Glu241Glu
M0210207 DIMEDMDJ_00363 442445 4 Gut 0.14 protein_coding synonymous_variant LOW 726C>A Val242Val
M0210208 DIMEDMDJ_00364 442585 3 Gut 0.10 protein_coding synonymous_variant LOW 66T>C Tyr22Tyr
M0210209 DIMEDMDJ_00364 442678 3 Gut 0.10 protein_coding synonymous_variant LOW 159C>G Ala53Ala
M0210210 DIMEDMDJ_00364 442777 5 Gut 0.17 protein_coding synonymous_variant LOW 258T>C Asp86Asp
M0210211 DIMEDMDJ_00364 442789 4 Gut 0.14 protein_coding synonymous_variant LOW 270A>G Lys90Lys
M0210212 DIMEDMDJ_00364 442792 5 Gut 0.17 protein_coding synonymous_variant LOW 273T>C Asp91Asp
M0210213 DIMEDMDJ_00364 442837 3 Gut 0.10 protein_coding synonymous_variant LOW 318A>G Glu106Glu
M0210214 DIMEDMDJ_00364 442852 3 Gut 0.10 protein_coding synonymous_variant LOW 333A>C Ala111Ala
M0210215 DIMEDMDJ_00364 442857 5 Gut 0.17 protein_coding missense_variant MODERATE 338A>G Lys113Arg
M0210216 DIMEDMDJ_00364 442924 4 Gut 0.14 protein_coding synonymous_variant LOW 405A>G Lys135Lys
M0210217 DIMEDMDJ_00364 443191 3 Gut 0.10 protein_coding synonymous_variant LOW 672A>G Ala224Ala
M0210218 DIMEDMDJ_00364 443323 4 Gut 0.14 protein_coding synonymous_variant LOW 804C>T Asn268Asn
M0210219 DIMEDMDJ_00366 444327 4 Gut 0.14 protein_coding synonymous_variant LOW 724T>C Leu242Leu
M0210220 DIMEDMDJ_00366 444449 3 Gut 0.10 protein_coding synonymous_variant LOW 846T>C Pro282Pro
M0210221 DIMEDMDJ_00363 442157 3 Gut 0.10 protein_coding synonymous_variant LOW 438G>A Glu146Glu
M0210222 DIMEDMDJ_00363 442172 3 Gut 0.10 protein_coding synonymous_variant LOW 453G>A Thr151Thr
M0210223 DIMEDMDJ_00363 442176 3 Gut 0.10 protein_coding missense_variant MODERATE 457A>T Thr153Ser
M0210224 DIMEDMDJ_00363 442214 3 Gut 0.10 protein_coding synonymous_variant LOW 495A>G Lys165Lys
M0210225 DIMEDMDJ_00363 442289 3 Gut 0.10 protein_coding missense_variant MODERATE 570C>A His190Gln
M0210226 DIMEDMDJ_00363 442290 3 Gut 0.10 protein_coding missense_variant MODERATE 571G>A Asp191Asn
M0210227 DIMEDMDJ_00363 442295 3 Gut 0.10 protein_coding synonymous_variant LOW 576C>A Ser192Ser
M0210228 DIMEDMDJ_00362 440443 5 Gut 0.17 protein_coding synonymous_variant LOW 78G>T Thr26Thr
M0210229 DIMEDMDJ_00362 441034 3 Gut 0.10 protein_coding synonymous_variant LOW 669C>T Ile223Ile
M0210230 DIMEDMDJ_00362 441130 6 Gut 0.21 protein_coding synonymous_variant LOW 765A>C Ser255Ser
M0210231 DIMEDMDJ_00362 440659 3 Gut 0.10 protein_coding synonymous_variant LOW 294C>T Asp98Asp
M0210232 DIMEDMDJ_00362 440785 4 Gut 0.14 protein_coding synonymous_variant LOW 420C>T Asn140Asn
M0210233 DIMEDMDJ_00362 440821 4 Gut 0.14 protein_coding synonymous_variant LOW 456C>A Gly152Gly
M0210234 DIMEDMDJ_00362 440923 4 Gut 0.14 protein_coding synonymous_variant LOW 558T>A Ser186Ser
M0210235 DIMEDMDJ_00362 441073 5 Gut 0.17 protein_coding synonymous_variant LOW 708T>C Ser236Ser
M0210236 DIMEDMDJ_00362 441228 4 Gut 0.14 protein_coding missense_variant MODERATE 863G>C Arg288Thr
M0210237 DIMEDMDJ_00363 442115 3 Gut 0.10 protein_coding synonymous_variant LOW 396C>T Val132Val
M0210238 DIMEDMDJ_00360 439033 3 Gut 0.10 protein_coding missense_variant MODERATE 175A>C Asn59His
M0210239 DIMEDMDJ_00360 439056 3 Gut 0.10 protein_coding synonymous_variant LOW 198A>C Val66Val
M0210240 DIMEDMDJ_00360 439194 3 Gut 0.10 protein_coding synonymous_variant LOW 336A>G Glu112Glu
M0210241 DIMEDMDJ_00360 439215 3 Gut 0.10 protein_coding missense_variant MODERATE 357T>G Asp119Glu
M0210242 DIMEDMDJ_00360 439233 3 Gut 0.10 protein_coding synonymous_variant LOW 375C>T Gly125Gly
M0210243 DIMEDMDJ_00360 439240 3 Gut 0.10 protein_coding synonymous_variant LOW 382T>C Leu128Leu
M0210244 DIMEDMDJ_00360 439251 3 Gut 0.10 protein_coding synonymous_variant LOW 393A>T Ala131Ala
M0210245 DIMEDMDJ_00360 439361 3 Gut 0.10 protein_coding missense_variant MODERATE 503A>C Asp168Ala
M0210246 DIMEDMDJ_00360 439446 3 Gut 0.10 protein_coding synonymous_variant LOW 588A>C Gly196Gly
M0210247 DIMEDMDJ_00360 439506 3 Gut 0.10 protein_coding synonymous_variant LOW 648G>A Ala216Ala
M0210248 DIMEDMDJ_00360 439536 3 Gut 0.10 protein_coding synonymous_variant LOW 678T>C Asp226Asp
M0210249 DIMEDMDJ_00360 439647 3 Gut 0.10 protein_coding synonymous_variant LOW 789C>T Phe263Phe
M0210250 DIMEDMDJ_00360 439713 3 Gut 0.10 protein_coding synonymous_variant LOW 855T>C Tyr285Tyr
M0210251 DIMEDMDJ_00360 439719 3 Gut 0.10 protein_coding synonymous_variant LOW 861C>T Ser287Ser
M0210252 DIMEDMDJ_00361 439777 3 Gut 0.10 protein_coding upstream_gene_variant MODIFIER -257G>T None
M0210253 DIMEDMDJ_00361 439910 3 Gut 0.10 protein_coding upstream_gene_variant MODIFIER -124T>A None
M0210254 DIMEDMDJ_00361 439943 3 Gut 0.10 protein_coding upstream_gene_variant MODIFIER -91C>A None
M0210255 DIMEDMDJ_00364 442561 3 Gut 0.10 protein_coding missense_variant MODERATE 42C>A Ser14Arg
M0210256 DIMEDMDJ_00364 442564 3 Gut 0.10 protein_coding missense_variant MODERATE 45A>C Lys15Asn
M0210257 DIMEDMDJ_00364 442565 3 Gut 0.10 protein_coding synonymous_variant LOW 46C>A Arg16Arg
M0210258 DIMEDMDJ_00364 442648 3 Gut 0.10 protein_coding synonymous_variant LOW 129G>T Ala43Ala
M0210259 DIMEDMDJ_00364 442651 3 Gut 0.10 protein_coding synonymous_variant LOW 132T>C Ile44Ile
M0210260 DIMEDMDJ_00364 442979 3 Gut 0.10 protein_coding synonymous_variant LOW 460C>T Leu154Leu






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
DIMEDMDJ_00380 ARO:3007119 98.6 0 1 639 1.0000 1.0000 tetracycline antibiotic tetracycline-resistant ribosomal protection protein antibiotic target protection
DIMEDMDJ_00381 ARO:3000567 98.8 5.39e-275 1 406 1.0000 1.0000 tetracycline antibiotic major facilitator superfamily (MFS) antibiotic efflux pump antibiotic efflux






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
DIMEDMDJ_00044 AUO20334.1|GH13_5 99 0 1 482 1 1
DIMEDMDJ_00098 AUO20372.1|CE12 99 0 1 867 1 1
DIMEDMDJ_00213 AUO20403.1|CE12|CE8 95.4 0 1 2135 1 1
DIMEDMDJ_00225 AUO20415.1|GH105 98.9 5.7e-285 1 366 1 1
DIMEDMDJ_00229 AUO20419.1|CE4 99.6 2.64e-198 1 269 1 1
DIMEDMDJ_00257 AUO18238.1|CBM13|PL1 99.3 0 1 708 1 1
DIMEDMDJ_00259 AUO18240.1|GH97 99.1 0 1 794 1 1
DIMEDMDJ_00266 AUO18245.1|GH77 98.2 0 1 493 1 1
DIMEDMDJ_00267 AUO18246.1|CE20 98.5 0 1 797 1 1
DIMEDMDJ_00282 AUO18261.1|CBM50 100 5.56e-144 1 202 1 1
DIMEDMDJ_00293 AUO18272.1|GH0 99.2 0 1 626 1 1
DIMEDMDJ_00408 AUO18387.1|CE12 99.5 0 1 1094 1 1
DIMEDMDJ_00434 AUO18413.1|GH13 99.5 0 1 436 1 1
DIMEDMDJ_00437 AUO18416.1|CBM50|GH18 99.3 1.63e-295 1 428 1 1
DIMEDMDJ_00440 AUO18419.1|GH0 98.5 2.24e-298 1 411 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term