Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1454
  Reference Plasmid   NZ_PP589762.1
  Reference Plasmid Size   57987
  Reference Plasmid GC Content   0.34
  Reference Plasmid Mobility Type   conjugative





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0116858 CPIHKHFO_00031 24413 4 Skin 0.33 protein_coding synonymous_variant LOW 480G>A Thr160Thr
M0116859 CPIHKHFO_00031 24473 3 Skin 0.25 protein_coding synonymous_variant LOW 540C>T Thr180Thr
M0116860 CPIHKHFO_00031 24525 5 Skin 0.42 protein_coding missense_variant MODERATE 592A>T Thr198Ser
M0116861 CPIHKHFO_00031 24591 5 Skin 0.42 protein_coding synonymous_variant LOW 658C>T Leu220Leu
M0116862 CPIHKHFO_00032 24713 5 Skin 0.42 protein_coding missense_variant MODERATE 85C>A Leu29Ile
M0116863 CPIHKHFO_00032 24744 5 Skin 0.42 protein_coding missense_variant MODERATE 116A>G Lys39Arg
M0116864 CPIHKHFO_00032 24760 5 Skin 0.42 protein_coding synonymous_variant LOW 132A>T Ala44Ala
M0116865 CPIHKHFO_00032 24825 5 Skin 0.42 protein_coding missense_variant MODERATE 197G>A Arg66Lys
M0116866 CPIHKHFO_00032 24829 3 Skin 0.25 protein_coding missense_variant MODERATE 201T>A Asn67Lys
M0116867 CPIHKHFO_00032 24835 3 Skin 0.25 protein_coding synonymous_variant LOW 207T>C Ile69Ile
M0116868 CPIHKHFO_00032 24840 5 Skin 0.42 protein_coding missense_variant MODERATE 212A>G Asn71Ser
M0116869 CPIHKHFO_00032 24854 3 Skin 0.25 protein_coding missense_variant MODERATE 226A>G Lys76Glu
M0116870 CPIHKHFO_00032 24898 5 Skin 0.42 protein_coding synonymous_variant LOW 270T>G Val90Val
M0116871 CPIHKHFO_00032 25091 5 Skin 0.42 protein_coding synonymous_variant LOW 463T>C Leu155Leu
M0116872 CPIHKHFO_00032 25219 5 Skin 0.42 protein_coding synonymous_variant LOW 591G>A Pro197Pro
M0116873 CPIHKHFO_00032 25222 5 Skin 0.42 protein_coding synonymous_variant LOW 594C>T Asp198Asp
M0116874 CPIHKHFO_00032 25226 5 Skin 0.42 protein_coding synonymous_variant LOW 598C>T Leu200Leu
M0116875 CPIHKHFO_00032 25415 5 Skin 0.42 protein_coding missense_variant MODERATE 787G>A Ala263Thr
M0116876 CPIHKHFO_00032 25437 5 Skin 0.42 protein_coding missense_variant MODERATE 809C>G Pro270Arg
M0116877 CPIHKHFO_00032 25450 5 Skin 0.42 protein_coding synonymous_variant LOW 822G>A Thr274Thr
M0116878 CPIHKHFO_00032 25483 5 Skin 0.42 protein_coding synonymous_variant LOW 855T>C Asp285Asp
M0116879 CPIHKHFO_00032 25484 5 Skin 0.42 protein_coding synonymous_variant LOW 856C>T Leu286Leu
M0116880 CPIHKHFO_00032 25742 4 Skin 0.33 protein_coding missense_variant MODERATE 1114C>T His372Tyr
M0116881 CPIHKHFO_00032 25845 5 Skin 0.42 protein_coding missense_variant MODERATE 1217G>A Ser406Asn
M0116882 CPIHKHFO_00032 25919 5 Skin 0.42 protein_coding missense_variant MODERATE 1291A>G Ser431Gly
M0116883 CPIHKHFO_00031 24179 3 Skin 0.25 protein_coding synonymous_variant LOW 246A>T Thr82Thr
M0116884 CPIHKHFO_00032 25339 3 Skin 0.25 protein_coding synonymous_variant LOW 711T>A Gly237Gly






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
CPIHKHFO_00011 ARE04809.1|GH73 100 0 1 616 1 1
OAKHGFOE_00011 ARE04809.1|GH73 100 0 1 616 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
CPIHKHFO_00027 3.A.1.124.5 98.8 1.5e-127 1 242 1.0000 0.7987 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
CPIHKHFO_00028 3.A.1.124.5 99.6 2.8e-126 1 249 1.0000 0.8218 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
CPIHKHFO_00029 3.A.1.124.5 99.3 5.3e-167 1 303 1.0000 1.0000 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
OAKHGFOE_00027 3.A.1.124.5 98.8 1.5e-127 1 242 1.0000 0.7987 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
OAKHGFOE_00028 3.A.1.124.5 99.6 2.8e-126 1 249 1.0000 0.8218 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
OAKHGFOE_00029 3.A.1.124.5 99.3 5.3e-167 1 303 1.0000 1.0000 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily