Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1466
  Reference Plasmid   OY725856.1
  Reference Plasmid Size   8501
  Reference Plasmid GC Content   0.49
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0211539 GGKCLLOD_00008 4694 10 Gut 0.36 protein_coding synonymous_variant LOW 231G>A Glu77Glu
M0211540 GGKCLLOD_00008 4695 10 Gut 0.36 protein_coding missense_variant MODERATE 232T>C Tyr78His
M0211541 GGKCLLOD_00008 4748 6 Gut 0.21 protein_coding synonymous_variant LOW 285T>C Thr95Thr
M0211542 GGKCLLOD_00008 4753 7 Gut 0.25 protein_coding missense_variant MODERATE 290C>T Thr97Ile
M0211543 GGKCLLOD_00008 4756 7 Gut 0.25 protein_coding missense_variant MODERATE 293A>G Asn98Ser
M0211544 GGKCLLOD_00008 4763 7 Gut 0.25 protein_coding synonymous_variant LOW 300G>A Ala100Ala
M0211545 GGKCLLOD_00009 4951 10 Gut 0.36 protein_coding synonymous_variant LOW 163T>C Leu55Leu
M0211546 GGKCLLOD_00009 4971 5 Gut 0.18 protein_coding synonymous_variant LOW 183A>C Pro61Pro
M0211547 GGKCLLOD_00009 5108 11 Gut 0.39 protein_coding missense_variant MODERATE 320G>A Arg107Gln
M0211548 GGKCLLOD_00009 5397 5 Gut 0.18 protein_coding synonymous_variant LOW 609A>G Glu203Glu
M0211549 GGKCLLOD_00009 5406 5 Gut 0.18 protein_coding synonymous_variant LOW 618C>T Asn206Asn
M0211550 GGKCLLOD_00009 5421 5 Gut 0.18 protein_coding synonymous_variant LOW 633G>A Glu211Glu
M0211551 GGKCLLOD_00009 5427 5 Gut 0.18 protein_coding synonymous_variant LOW 639G>T Gly213Gly
M0211552 GGKCLLOD_00009 5493 3 Gut 0.11 protein_coding synonymous_variant LOW 705T>C His235His
M0211553 GGKCLLOD_00009 5541 7 Gut 0.25 protein_coding synonymous_variant LOW 753A>G Glu251Glu
M0211554 GGKCLLOD_00009 5544 6 Gut 0.21 protein_coding synonymous_variant LOW 756G>A Lys252Lys
M0211555 GGKCLLOD_00009 5567 5 Gut 0.18 protein_coding missense_variant MODERATE 779A>G Lys260Arg
M0211556 GGKCLLOD_00009 5568 6 Gut 0.21 protein_coding synonymous_variant LOW 780G>A Lys260Lys
M0211557 GGKCLLOD_00009 5608 6 Gut 0.21 protein_coding missense_variant MODERATE 820A>G Thr274Ala
M0211558 GGKCLLOD_00001 70 6 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -21T>C None
M0211559 GGKCLLOD_00001 643 6 Gut 0.21 protein_coding missense_variant MODERATE 553T>G Ser185Ala
M0211560 GGKCLLOD_00001 939 4 Gut 0.14 protein_coding synonymous_variant LOW 849T>C Phe283Phe
M0211561 GGKCLLOD_00001 955 4 Gut 0.14 protein_coding missense_variant MODERATE 865C>G Pro289Ala
M0211562 GGKCLLOD_00001 963 6 Gut 0.21 protein_coding synonymous_variant LOW 873A>T Ile291Ile
M0211563 GGKCLLOD_00001 1050 3 Gut 0.11 protein_coding synonymous_variant LOW 960G>A Thr320Thr
M0211564 GGKCLLOD_00001 1098 3 Gut 0.11 protein_coding synonymous_variant LOW 1008C>T Arg336Arg
M0211565 GGKCLLOD_00001 1116 5 Gut 0.18 protein_coding synonymous_variant LOW 1026C>T Arg342Arg
M0211566 GGKCLLOD_00001 1128 5 Gut 0.18 protein_coding synonymous_variant LOW 1038C>T Tyr346Tyr
M0211567 GGKCLLOD_00001 1134 5 Gut 0.18 protein_coding synonymous_variant LOW 1044C>T Cys348Cys
M0211568 GGKCLLOD_00001 1137 5 Gut 0.18 protein_coding synonymous_variant LOW 1047A>C Ser349Ser
M0211569 GGKCLLOD_00001 1490 4 Gut 0.14 protein_coding missense_variant MODERATE 1400C>T Ala467Val
M0211570 GGKCLLOD_00001 1504 3 Gut 0.11 protein_coding missense_variant MODERATE 1414A>G Ile472Val
M0211571 GGKCLLOD_00001 1518 4 Gut 0.14 protein_coding synonymous_variant LOW 1428A>G Glu476Glu
M0211572 GGKCLLOD_00001 1520 5 Gut 0.18 protein_coding missense_variant MODERATE 1430C>A Thr477Lys
M0211573 GGKCLLOD_00001 1560 3 Gut 0.11 protein_coding synonymous_variant LOW 1470T>C Asp490Asp
M0211574 GGKCLLOD_00001 1620 4 Gut 0.14 protein_coding synonymous_variant LOW 1530T>C Ile510Ile
M0211575 GGKCLLOD_00001 1636 5 Gut 0.18 protein_coding missense_variant MODERATE 1546A>G Asn516Asp
M0211576 GGKCLLOD_00001 1689 3 Gut 0.11 protein_coding synonymous_variant LOW 1599C>T Phe533Phe
M0211577 GGKCLLOD_00008 4751 4 Gut 0.14 protein_coding synonymous_variant LOW 288C>T His96His
M0211578 GGKCLLOD_00009 4918 5 Gut 0.18 protein_coding missense_variant MODERATE 130C>A Arg44Ser
M0211579 GGKCLLOD_00009 4920 5 Gut 0.18 protein_coding synonymous_variant LOW 132C>A Arg44Arg
M0211580 GGKCLLOD_00009 4941 6 Gut 0.21 protein_coding synonymous_variant LOW 153T>C Ser51Ser
M0211581 GGKCLLOD_00009 4944 3 Gut 0.11 protein_coding synonymous_variant LOW 156C>T Asp52Asp
M0211582 GGKCLLOD_00009 5428 4 Gut 0.14 protein_coding missense_variant MODERATE 640C>A Leu214Ile
M0211583 GGKCLLOD_00009 5451 4 Gut 0.14 protein_coding synonymous_variant LOW 663A>G Arg221Arg
M0211584 GGKCLLOD_00009 5643 3 Gut 0.11 protein_coding synonymous_variant LOW 855G>A Ala285Ala
M0211585 GGKCLLOD_00009 5718 4 Gut 0.14 protein_coding synonymous_variant LOW 930A>G Ala310Ala
M0211586 GGKCLLOD_00009 5797 3 Gut 0.11 protein_coding missense_variant MODERATE 1009A>T Thr337Ser
M0211587 GGKCLLOD_00009 5799 3 Gut 0.11 protein_coding synonymous_variant LOW 1011T>C Thr337Thr
M0211588 GGKCLLOD_00009 6088 4 Gut 0.14 protein_coding missense_variant MODERATE 1300T>A Ser434Thr
M0211589 GGKCLLOD_00009 6093 4 Gut 0.14 protein_coding missense_variant MODERATE 1305C>A Asp435Glu
M0211590 GGKCLLOD_00009 6121 3 Gut 0.11 protein_coding missense_variant MODERATE 1333G>A Glu445Lys
M0211591 GGKCLLOD_00009 6123 3 Gut 0.11 protein_coding missense_variant MODERATE 1335A>C Glu445Asp
M0211592 GGKCLLOD_00009 6145 3 Gut 0.11 protein_coding missense_variant MODERATE 1357G>A Ala453Thr
M0211593 GGKCLLOD_00009 6147 3 Gut 0.11 protein_coding synonymous_variant LOW 1359T>C Ala453Ala
M0211594 GGKCLLOD_00009 6236 4 Gut 0.14 protein_coding missense_variant MODERATE 1448A>T His483Leu
M0211595 GGKCLLOD_00010 6314 4 Gut 0.14 protein_coding synonymous_variant LOW 33G>A Ala11Ala
M0211596 GGKCLLOD_00001 102 4 Gut 0.14 protein_coding synonymous_variant LOW 12T>C Asn4Asn
M0211597 GGKCLLOD_00001 270 5 Gut 0.18 protein_coding synonymous_variant LOW 180C>T Ser60Ser
M0211598 GGKCLLOD_00001 273 5 Gut 0.18 protein_coding synonymous_variant LOW 183C>T Gly61Gly
M0211599 GGKCLLOD_00001 276 5 Gut 0.18 protein_coding synonymous_variant LOW 186C>T Thr62Thr
M0211600 GGKCLLOD_00001 315 3 Gut 0.11 protein_coding synonymous_variant LOW 225G>A Glu75Glu
M0211601 GGKCLLOD_00001 318 3 Gut 0.11 protein_coding synonymous_variant LOW 228T>G Val76Val
M0211602 GGKCLLOD_00001 339 3 Gut 0.11 protein_coding synonymous_variant LOW 249T>C Tyr83Tyr
M0211603 GGKCLLOD_00001 340 5 Gut 0.18 protein_coding synonymous_variant LOW 250T>C Leu84Leu
M0211604 GGKCLLOD_00001 345 4 Gut 0.14 protein_coding synonymous_variant LOW 255C>T Cys85Cys
M0211605 GGKCLLOD_00001 387 6 Gut 0.21 protein_coding synonymous_variant LOW 297T>C Val99Val
M0211606 GGKCLLOD_00001 552 4 Gut 0.14 protein_coding synonymous_variant LOW 462A>C Ser154Ser
M0211607 GGKCLLOD_00001 687 5 Gut 0.18 protein_coding synonymous_variant LOW 597T>C Gly199Gly
M0211608 GGKCLLOD_00001 714 5 Gut 0.18 protein_coding synonymous_variant LOW 624A>G Lys208Lys
M0211609 GGKCLLOD_00001 721 5 Gut 0.18 protein_coding missense_variant MODERATE 631T>G Ser211Ala
M0211610 GGKCLLOD_00001 722 5 Gut 0.18 protein_coding stop_gained HIGH 632C>A Ser211*
M0211611 GGKCLLOD_00001 723 5 Gut 0.18 protein_coding synonymous_variant LOW 633G>A Ser211Ser
M0211612 GGKCLLOD_00001 729 5 Gut 0.18 protein_coding synonymous_variant LOW 639G>A Lys213Lys
M0211613 GGKCLLOD_00001 732 5 Gut 0.18 protein_coding synonymous_variant LOW 642G>T Val214Val
M0211614 GGKCLLOD_00001 735 5 Gut 0.18 protein_coding synonymous_variant LOW 645T>C Leu215Leu
M0211615 GGKCLLOD_00001 744 5 Gut 0.18 protein_coding synonymous_variant LOW 654T>C Ser218Ser
M0211616 GGKCLLOD_00001 759 5 Gut 0.18 protein_coding synonymous_variant LOW 669A>G Gln223Gln
M0211617 GGKCLLOD_00001 783 3 Gut 0.11 protein_coding synonymous_variant LOW 693C>T Asn231Asn
M0211618 GGKCLLOD_00001 849 5 Gut 0.18 protein_coding synonymous_variant LOW 759G>A Glu253Glu
M0211619 GGKCLLOD_00001 1344 3 Gut 0.11 protein_coding synonymous_variant LOW 1254A>C Thr418Thr
M0211620 GGKCLLOD_00001 1410 3 Gut 0.11 protein_coding synonymous_variant LOW 1320C>A Gly440Gly
M0211621 GGKCLLOD_00009 5115 3 Gut 0.11 protein_coding synonymous_variant LOW 327A>G Leu109Leu
M0211622 GGKCLLOD_00009 6189 3 Gut 0.11 protein_coding synonymous_variant LOW 1401T>C Cys467Cys
M0211623 GGKCLLOD_00009 6233 3 Gut 0.11 protein_coding missense_variant MODERATE 1445T>A Met482Lys
M0211624 GGKCLLOD_00010 6425 3 Gut 0.11 protein_coding synonymous_variant LOW 144A>G Lys48Lys
M0211625 GGKCLLOD_00010 6506 3 Gut 0.11 protein_coding synonymous_variant LOW 225C>T Ala75Ala
M0211626 GGKCLLOD_00011 8258 3 Gut 0.11 protein_coding upstream_gene_variant MODIFIER -39T>C None
M0211627 GGKCLLOD_00001 201 4 Gut 0.14 protein_coding synonymous_variant LOW 111T>A Ala37Ala
M0211628 GGKCLLOD_00001 648 3 Gut 0.11 protein_coding synonymous_variant LOW 558A>C Ala186Ala
M0211629 GGKCLLOD_00001 684 3 Gut 0.11 protein_coding missense_variant MODERATE 594G>C Glu198Asp
M0211630 GGKCLLOD_00001 933 3 Gut 0.11 protein_coding synonymous_variant LOW 843G>A Thr281Thr
M0211631 GGKCLLOD_00009 5136 7 Gut 0.25 protein_coding synonymous_variant LOW 348T>G Arg116Arg
M0211632 GGKCLLOD_00009 6039 3 Gut 0.11 protein_coding synonymous_variant LOW 1251A>C Arg417Arg
M0211633 GGKCLLOD_00008 4571 3 Gut 0.11 protein_coding synonymous_variant LOW 108A>G Lys36Lys
M0211634 GGKCLLOD_00008 4706 4 Gut 0.14 protein_coding synonymous_variant LOW 243T>C Ser81Ser
M0211635 GGKCLLOD_00009 4866 3 Gut 0.11 protein_coding synonymous_variant LOW 78T>A Arg26Arg
M0211636 GGKCLLOD_00004 3181 4 Gut 0.14 protein_coding missense_variant MODERATE 350G>A Ser117Asn
M0211637 GGKCLLOD_00004 3241 3 Gut 0.11 protein_coding missense_variant MODERATE 410C>T Ala137Val
M0211638 GGKCLLOD_00005 3550 4 Gut 0.14 protein_coding synonymous_variant LOW 258T>C Asn86Asn
M0211639 GGKCLLOD_00005 3691 3 Gut 0.11 protein_coding synonymous_variant LOW 399C>T Tyr133Tyr






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term